辛能润是中药药性理论的重要组成部分，最早见于《素问•藏气法时论》：“肾苦燥，急食辛以润之……” ，把“润燥”作为辛味药的功效之一。然而目前鲜有研究对于这一理论进行系统探索。张仲景所著经典方当归芍药散正是在健脾利湿和血药物中配伍了辛温之川芎、当归，临床研究证实配伍辛味药物后显著加强了对肝肾亏虚型老年性痴呆（Alzheimer’s Disease ，AD）的防治作用。因此本课题拟运用拆方研究方法，将当归芍药散分为全方组和去辛温活血药当归、川芎的拆方组，利用诱导多能干细胞技术建立肝肾亏虚型AD人源模型，考察辛味药物对于肝肾亏虚型AD的防治作用以及对经典通路IGF1-IRS-Akt细胞生存信号级联通路的影响，丰富和发展“辛能润”的药性理论内涵。

Xin-run theory of Chinese medicine is an important part in the property theory of nature and flavor of Chinese materia medica, which first appeared in the Huangdi Nei-jing (Yellow Emnerors Internal Classic) illustrated as used acrid herbs when liver and kidney deficiency. However, the theory of nourish liver and kidney deficiency with acrid herbs has little systematic research on this theory. Danggui Shaoyao Powder is the classical formula found by Zhang Zhongjing which consisted with strengthening spleen and removing dampness and activating blood compatibility with Ligusticum Chuanxiong and Angelica Sinensis. The clinicla reseach supported that the compatibility with Ligusticum Chuanxiong and Angelica Sinensis could significantly strengthen the liver and kidney deficiency type of senile dementia (Alzheimer 's Disease, AD) . By using the method of dismantlement study that divided Danggui Shaoyao Powder into whole group and blood activating drugs drugs angelica and Chuanxiong prescription group, and establishing liver and kidney deficiency type of AD humanization animal model with hiPSC technology ,this study is aim to explore the effect and mechanism of acrid herbs on the AD and the influence of IGF1-IRS-Akt cell survival signaling cascade classical pathway, to enrich and develope the Xin-run theory of Chinese medicine.