中西医结合医学是我国三大医疗实践体系之一，国家《中医药发展战略规划纲要（ 2016—2030 年）》特别提出要坚持中西医并重，促进中西医结合发展。临床实践指南是提高中西医结合医疗服务质量和安全性、促进新的研究成果在临床上推广应用的重要工具。但中西医结合指南制定关键技术方法学体系尚不完善，特别是中西医结合指南制定过程中的非证据关键因素（患者偏好和价值观，经济学因素）迄今没有一个可操作的规范标准，严重影响着中西医结合临床实践指南的质量。本研究借鉴国内外指南制定方法学研究成果，针对中西医结合临床实践指南的特殊性，通过文献回顾、系统评价、德尔菲法及面对面专家共识等方法，探索解决中西医结合指南制定非证据关键因素的方法学问题，构建中西医结合指南制订非证据因素关键技术方法学体系，为推进中西医结合继承创新发展服务。

Chinese integrative medicine, one of the three health practice systems in China, is increasingly accepted by clinicians and patients. Strategic plan for development of Chinese traditional medicine (2016—2030) emphasizes that we should focus both on western medicine and Chinese traditional medicine, then promotes the Chinese integrative medicine. Clinical practice guideline is a critical tool aiming at improving the quality and safety of health service, enabling proper clinical decision, and promoting the implementation of qualified evidence in practice. But there are still some problems in the consideration and practice of the two critical non-evidence factors (economic factor and value and preference of patients) in Chinese integrative medicine guideline development. In consideration of the characteristics of integrative medicine, existing methods for western medicine are not suitable, and there is no tool or criteria tailored for integrative medicine, which influences the quality of Chinese integrative medicine guideline remarkably. Thus, this program aims at exploring and developing system of the key technologies in integrative medicine guideline development. We will combine literature review, systematic review, expert consultation, Delphi method and face-to-face consensus meeting in this program, and solve the methodology problems in the economic factor and value and preference of patients of developing integrative medicine guidelines. Then a web-based methodological system will be constructed based on the acquired knowledge of the critical technologies.