脑卒中是严重危害社会健康的常见疾病，也是引起成人残疾的首要因素。探索新型运动康复技术、开发运动辅助新设备已成为世界范围，尤其是我国关注的焦点。而镜像神经元和大脑可塑性康复机制研究亦成为当前神经科学研究的前沿热点。课题拟针对传统康复训练无法有效实现多手段协同强化诱导运动功能的难题，结合功能性电刺激、机械外骨骼及助行辅具技术手段，开发肌骨动力助行新方法；深入研究镜像神经元系统在卒中康复中的神经机制，并结合经颅电磁刺激前沿技术建立面向脑-机-肌-骨框架的多模物理刺激协同诱导模型；开展基于脑电和核磁成像技术的镜像神经元及可塑性分析研究，探索强化镜像神经元激活特性与中枢神经可塑性诱导功效的关键措施，建立新型康复评价客观标准。本研究将为推进中枢神经可塑性康复机制深入研究提供新的科学依据和实用模型，并为研制多功能融合的新型智能化运动功能辅助系统奠定关键技术基础。

Stroke is a common disease with high incidence severely threatening the health of human beings as well as a primary factor leading to human disability. The investigation of novel walk-aid rehabilitation technology and development of motion function auxiliary system have become new research focus in worldwide, especially in China. Meanwhile, the mirror neuron and mechanism of brain plasticity rehabilitation have also developed into a researching hotspot of neuroscience. Aiming at the problem that traditional rehabilitation training cannot implement reinforcement of motor function through multi-methods, this project attempts to develop new walk-aid method with musculoskeletal dynamics combining functional electrical stimulation, mechanical exoskeleton and walking-aid technology. Besides, this project provides a profound research on the neural mechanism of mirror neuron system in stroke rehabilitation and builds inducing model of multi-modality physical stimulation facing brain-computer-muscle-skeleton frame combining with transcranial electrical and magnetic stimulation technology. This project will also investigate the mirror neuron and plasticity analysis based on EEG and fMRI technology, explore key measures of strengthening mirror neuron activation and effect of neural plasticity inducement, and establish objective rehabilitation evaluation standards. This project will provide scientific basis and practical model for in-depth investigation of central neural plasticity rehabilitation mechanism. Furthermore, it will also provide key technologies for developing a novel intelligent motion function auxiliary system with multi-function.