近年来，银屑病患者合并脂代谢紊乱呈显著增高趋势，并成为影响患者生存质量的潜在危险因素，相关机制尚不明确，是目前研究的热点问题。肿瘤坏死因子-α（TNF-α）及其激活的过氧化物酶体增生物激活受体（PPAR-β/δ）是联系先天免疫和脂质代谢紊乱之间的桥梁，与银屑病和脂代谢紊乱密切相关。“湿瘀毒互结”是银屑病和脂代谢紊乱的共同病机。凉血解毒方是北京中医医院皮肤科治疗银屑病血热证的有效方剂，临床观察和基础实验均证实其具有较好的疗效，并能够调节患者的糖脂类代谢。基于TNF-α/PPAR-β/δ通路，观察凉血解毒方对咪喹莫特诱导ApoE-/-小鼠银屑病样皮损（PASI评分、病理学改变）和血脂水平以及TNF-α等炎症因子和PPAR-β/δ通路的影响，并通过脂质代谢组学和生物信息学验证药物作用的靶点和信号通路，探讨中药复方治疗银屑病合并脂代谢紊乱的作用机制，为临床治疗奠定理论基础和科学依据。

In recent years, psoriasis patients accompanied with dyslipidemia is significantly increasing, and has become a potential risk factor affecting patients quality of life, but the relevant mechanism is unclear, which is a hot topics in research field. Tumor necrosis factor-α (TNF-α) is a link between innate immunity and lipid metabolism disorders, as well as peroxisome proliferator-activated receptor (PPAR-β/δ) ,which is closely related with psoriasis and dyslipidemia. "Dampness, stasis and toxicity accumulation" is the common pathogenesis of psoriasis and dyslipidemia.LiangXueJieDu Fang(LXJDF) is a Chinese herbal compound for the treatment of psoriasis blood-heat syndrome in Dermatology Department of Beijing Chinese Medicine Hospital, its curative effect has been verified in clinical research and basic experiments，especially it could regulate glycolipid metabolism.Based on TNF-α/PPAR-β/δ pathway, we observe influence of Liangxuejiedu Fang on imiquimod induced ApoE-/- mice psoriasis-like lesions (PASI score, pathological changes), lipid levels, TNF-α and other inflammatory cytokines and PPAR-β/δ pathway. Moreover, we try to validate drug targets and signaling pathways through Lipid Metabonomics and Bioinformatics, to discuss the mechanism of Chinese herbal compound treatment on psoriasis and dyslipidemia comorbidity, and provide theoretical foundation and scientific evidence for clinical treatment.