在气体信号分子与心血管调节领域取得重要突破，首次发现心血管系统存在内源性二氧化硫体系，揭示其具有重要的心血管生理及病理生理学效应及机制，提出“内源性二氧化硫为心血管调节的新的气体信号分子”；发现硫化氢调控染色质重塑的表观遗传学模式，揭示硫化氢对靶蛋白NF-κB的硫氢化修饰机制。发表SCI论文107篇，其中以第一/通讯作者在JACC(IF=16.5)及JBC等发表SCI论文70篇，被SCI总引1184次，其中SCI他引836次，得到国际同行关注与认可，应邀在CEPP及OMCL等杂志发表评论与综述，在国际学术大会作特邀讲座。当选国家青年拔尖人才、教育部新世纪优秀人才和北京科技新星。下一步将以p65及其关键巯基为靶点，揭示内源性二氧化硫对动脉粥样硬化血管炎症的调节作用，阐明其对p65次磺化修饰的新机制，揭示二氧化硫和硫化氢的整合调节模式，以期深化含硫气体信号分子对动脉粥样硬化血管炎症的调节机制。

Focusing on the endogenous gaseous signaling molecules and cardiovascular regulation, the applicant obtained the following breakthroughs. For the first time, the applicant demonstrated that endogenous sulfur dioxide pathway existed in cardiovascular tissues, played important physiological and pathophysiological roles in cardiovascular system, and disclosed its regulatory mechanisms. Accordingly, the applicant put forward a new concept that endogenous sulfur dioxide is a novel cardiovascular gasotransmitter. The applicant discovered the epigenetic mechanisms by which hydrogen sulfide controls the chromatin remodeling and the sulfhydration modification on nuclear factor-kB (NF-kB). The applicant has published totally 107 SCI papers, including 70 SCI papers as the first author/corresponding author in journals such as JACC(IF=16.5) and JBC, etc. The publications were cited for 1184 times totally, among which 836 times by other research teams in their SCI papers. The applicant was invited to publish editorial or review articles in CEPP, OMCL and other SCI journals and give lecture in the international academic conference. The academic titles National Outstanding Young Scholar by the Organization Department of the Central Committee of CPC, New Century Excellent Talents by Ministry of Education, P.R. China and the New Star of Beijing Science and Technology were given to the applicant. In further studies, targeting on the p65 and its key thiol group, the applicant plans to investigate the effect of endogenous sulfur dioxide on the vascular inflammation during the development of atherosclerosis and demonstrate the sulfenic acid modification of sulfur dioxide on the free thiol group in p65. Finally, the applicant plans to explore the integrated regulation between hydrogen sulfide and sulfur dioxide. Based on the above studies, the applicant aims to deepen the understanding of the mechanisms by which endogenous sulfur-containing gases regulate vascular inflammatory response in atherosclerosis.