随着医疗卫生事业的快速发展，人口的预期寿命显著延长，老龄化问题日益突出。衰老引起的相关疾病发病率逐年上升，是全球面临的重大公共卫生问题。目前，小鼠早衰模型被广泛应用于探索衰老发生发展机制及干预策略的研究。JWA是新的环境应答基因，具有多种活跃的生物学功能，包括参与ROS引起的DNA损伤修复。课题组前期采用Cre-LoxP技术构建了JWA基因第二外显子剔除小鼠，该小鼠出现典型的早衰表型，中位生存时间为5.8个月，是较理想的小鼠早衰模型。本研究拟对JWA基因剔除小鼠生命周期不同阶段进行系统的表型分析，以小鼠自然衰老过程中组织器官、生理生化变化、免疫等变化特征为参照，试图建立原创性的生命周期适中、衰老特征明确、器官组织和分子变化规律明显的小鼠衰老模型及其数据库，为阐明衰老发生和发展机制，寻找有效干预策略提供新的有价值的小鼠衰老动物模型；JWA LoxP 模型小鼠还可广泛用于靶器官毒理学研究。

Life expectancy has been significantly prolonged due to the rapid development of medical and health care. However, the incidence of age-related diseases has increased year by year, which is the inevitable public health problem. Premature aging mouse models have been widely used in exploring the mechanisms of aging and the strategies to anti-aging and age-related diseases. JWA is a novel environment-responsive gene and is upregulated by oxidative stress to repair the damaged DNA. We have generated the JWA gene knockout mice via Cre-LoxP system. JWA deficient mice exhibit typical premature aging phenotype and the median survive time is 5.8 months, which is regarded as the ideal aging mouse model. In this study, we will systematically analyze the phenotype changes of JWA wild type and knockout mice during their life span and the results will be access for scientists in this field, which could be helpful for aging research. In addition, JWA LoxP mice could be used for toxicological studies of organ-targets.