申请人从事环氧化酶（COX）同工酶在炎症反应调节和心血管疾病中作用研究13年。近五年在J Clin Invest, Sci Transl Med, Circ Res, J Allergy Clin Immunol, Diabetes和Blood等杂志上发表通讯作者论文9篇和综述1篇。提出了COX-2来源的PGI2通过肾脏和血管共同调节血压的新理论；解析了COX-2促进血管损伤后重塑的新信号通路；揭示了PGE2受体EP3促进低氧诱导肺动脉重塑中作用的新机制；发现了阿司匹林与深海鱼油联用抗血管重塑的新功效；揭示维生素D抑制COX-2介导的炎症反应的新途径；发现了COX-1调节淋巴细胞免疫的新功能。这些工作丰富了COX在调节炎症和血管稳态平衡的理论知识，为合理使用NSAID提供了依据；并受到Science、Circ Res等杂志专评。今后将继续深入研究COX通路在炎症反应和血管稳态平衡中的作用。

The applicant has being engaged in studying COXs and their down-stream pathways involved in inflammatory response and cardiovascular diseases over 13 years. In recent five years, as corresponding author, he has published 9 research articles in the prestigious journals, such as J Clin Invest, J Allergy Clin Immunol, Sci Transl Med, Circ Res, Blood, Diabetes, Br J Pharmacol, J Biol Chem, and Cardiovasc Toxicol, and 1 review in Front Pharmacol. During the past several years, his work came to a conclusion that COX-2 derived PGI2 in vessel wall and kidney participates in blood pressure regulation; revealed the molecular mechanisms for COX-2-derived PGE2 involvement in injury-induced arterial remodeling; discovered the novel mechanisms for PGE2 receptor subtype 3 (EP3) in hypoxia-induced pulmonary vascular remodeling in pulmonary hypertension; unveiled the novel function of aspirin and fish oil combination on inhibiting vascular remodeling; revealed the novel approach of vitamin D to suppression of COX-2-mediated inflammation; discovered the new roles of COX-1 on lymphocyte immune. All these work increased our knowledge on inflammation response and vascular homeostasis with COX involvement and provided evidences for proper usage of NSAIDs. Because of these achievements, some of his work have gained special comments from the high-profile journals, such as Science and Circ Res. Further work in his laboratory will continue to investigate COXs and downstream pathways implicated in inflammatory reaction and vascular homeostasis.