断裂力学认为固体材料在应力负荷下产生裂纹破坏，作为生物材料的骨骼更是如此。裂纹扩展是骨质微损伤，微骨折发展到骨质疏松性骨折最关键的中间进程。中药补肾法能有效提高骨质量及骨微结构，但对其干预疏松骨结构破坏的力学机制仍不清楚。研究骨材料结构提升对裂纹扩展的作用是骨质疏松防治在断裂力学方向的重要突破口之一。本项目研究拟①基于骨质疏松大鼠模型进行补肾药物干预，结合微结构材质影像学，研究三维体视计量学参数和三维骨矿含量、骨体积密度等骨密度参数与有限元模型的关系；②根据有限元数据及生物力学参数、断裂失效值、裂纹扩展系数等优化结果，建立基于材料参数与载荷条件等的大鼠股骨骨质疏松断裂风险的多元逻辑回归模型；③通过有限元研究与验证，分析补肾法干预过程中各时间点对大鼠股骨微结构材质及裂纹扩展的断裂力学规律。探明补肾法影响裂纹扩展的作用机制及与骨折的相关性，为防治疏松性骨折的深入研究提供新理论和实验基础。

Under the fracture mechanics there is crack in bone biomaterial, in particular osteoporosis bone. Crack propagation is the key intermediate of osteoporotic fracture process from microdamage, and microfracture. The application of tonifying kidney method of Chinese Medicine can improve bone mineral density and bone trabecular structure, but the effective mechanical mechanism to prevent osteoporotic fractures is still unclear. Improved bone quality may affect the outcome of crack propagation can be an important breakthrough of bone materialogy. So, In present research (1) based on osteoporosis rats model of drug intervention, we combined with the microstructure of material imaging to study fracture mechanics in multidimensional and study the relationship between three-dimensional visual metrology parameters, bone mineral content, bone density parameters and the finite element model;(2) according to the results of the finite element analysis of data, biomechanics material parameters ,fracture failure and crack propagation, we build rat proximal femoral osteoporosis fracture risk of multivariate logistic regression model;(3)through the finite element analysis method and its verification, we investigate all time points in the process of tonifying kidney intervention how to influence rat femoral microstructure material and the variation regularity of crack propagation. To prove the mechanism that method of tonifying kidney affect the action of crack propagation, so as to the correlation with osteoporosis fracture. Finally, to provide new theoretical and experimental research for the prevention and treatment of osteoporosis fracture.