糖尿病冠心病（DCHD）是糖尿病大血管病变之一，与糖代谢紊乱、血脂紊乱、肥胖、高血压、炎症因子等多种危险因素关系密切，氧化应激贯穿其中。单因素强化降糖无法减少大血管事件，而现有指南中多危险因素控制治疗策略，亦尚未取得满意效果，探索新治则治法急迫而重要。中医药在此方面具有天然优势，项目组前期研究证实“肝郁脾枢失运为本，湿痰瘀浊内阻为标”是DCHD基本病机之一，首提“调肝启枢化浊”法综合防治糖脂代谢病及其血管并发症，代表方通过调节脂质吸收、合成、转运、转化、排泄和胰岛素信号通路、改善胰岛素抵抗、抗炎、抗动脉硬化等多环节、多靶点发挥作用，相关成果获国家科技进步二等奖和中国优秀专利奖。基于此，本项目拟运用分子生物学、脂、糖组学等方法，围绕“浊-氧化应激”核心病理，从临床、动物、细胞层次探讨调肝启枢化浊法防治DCHD效应特点和作用机制，以期提供一种切实有效的治则治法和相应方药，同时丰富中医病机学说。

Diabetic coronary heart disease (DCHD), to which several risk factors including glucose and lipid metabolic disorders, obesity, hypertension and inflammatory factors contribute, is one of the diabetes macroangiopathies . Oxidative stress is a crucial part under the pathological condition..Intensive glucose lowering by single method can’t reduce macro-vascular events, while the treatment strategy in the existing guideline by multiple methods can’t reach satisfying efficacy. It’s of urgent need to explore a new therapeutic strategy and method..Chinese medicine has a natural advantage in these diseases, our previous studies confirmed that “Gan-depression and Pi-mis-transportation as fundamental, phlegm-damp-stasis stagnation as manifestation” is one of the basic pathogenesis of DCHD. We first proposed the method “TiaoGan QiShu HuaZhuo (Modulating Gan, to trigger Pi-hub with subsquent phlegm-damp-stasis clean)” as integrated control of glucose and lipid metabolism diseases and their vascular complications. Representative prescriptions of this method exert effects of multi-links and multi-targets on DCHD, by regulating lipid absorption, synthesization, transportation, transformation and excretion as well as regulating insulin signaling to ameliorate insulin resistance, anti-inflammation, anti-atherosclerosis, and so on. Relevant achievements have won the second prize of National Scientific and Technological Progress Award and National Outstanding Patent Award. .Base on the above, in this study, we intend to use molecular technology, glycomics and lipidomics etc., focusing on the key pathology of “glycolipid toxicity - oxidant stress”, to explore the effective profiles and mechanisms of the very “TiaoGan QiShu HuaZhuo” method on DCHD, using clinical trials, and in vivo/in vitro experiments. We expect to sum up some effective treatments with a series of prescriptions, meanwhile enriching TCM pathogenesis theory.