本项目依托于北京大学第一医院、北京大学第三医院等协作单位，利用统一的研究规范和标准，设计前瞻性队列研究，建立复发流产和子痫前期等妊娠疾病的病例-对照队列和资源库；收集孕妇妊娠前和妊娠不同阶段血样、羊水以及分娩胎盘、脐带、脐带血、婴儿血样等，完善和丰富中国人群的妊娠疾病标本库，实现标本库的统一电子管理和资源共享。同时评估外周循环和母胎界面上特异标记分子对子痫前期和复发流产的早期预测价值，对预测价值较好的标记分子，积极推进开展多中心、大样本、分层次的临床随机对照试验，提出将标记分子组合与临床特征相结合的综合预测方案。此外，对子痫前期和复发流产的高危人群进行预防性临床干预研究。

This study aims to construct a prospective case-control cohort of recurrent spontaneous abortion and preeclampsia patients, which is based on the resources of Peking University First Hospital, Peking University Third Hospital and other collaborative medical centers. It is planned to collect plasma specimens, amniotic fluid, placental specimens, cord blood samples and infantile blood samples , in order to reinforce the gestational sample library of Chinese people. Uniform and standardized electronic management will be used in the database. All the samples will be shared throughout all medical centers. Meanwhile, by means of such sample library, predictive values of serum and placental specific biomarkers will be evaluated. Thereafter, multicentric large randomized clinical trials will be carried out to verify the predictive values of promising markers, which will probably give rise to a combined protocol for the prediction of preeclampsia and recurrent spontaneous abortion. Moreover , prophylatic clinical trials will also be conducted to assess prophylatic treatments on preventing preeclampsia and recurrent spontaneous abortion.