功能性肠病发病率约为30-50%，肠道动力异常是功能性肠病的病理基础。针灸治疗功能性肠病的有效率在80%-95%之间，能有效改善肠道动力异常。我们前期研究发现针刺大肠俞募穴均可双向调整腹泻和便秘患者的肠道动力异常，且通过fMRI 发现其中枢响应特征。目前亟需回答的问题是其分子机制是什么？为此我们提出"电针大肠俞募配穴通过脑肠经穴互动方式双向调节肠道动力异常，当肠道动力亢进出现腹泻时，一方面大肠俞募配穴可直接减少结肠黏膜下神经丛的BDNF 表达并抑制BDNF-TrkB 信号系统传导，另一方面通过促进海马BDNF 表达并形成抑制肠道BDNF-TrkB 信号系统传导的负反馈环路；当肠道动力减弱出现便秘时其作用机制则相反"的工作假说，运用多学科技术方法，分析大鼠的海马及结肠黏膜神经丛的BDNF-TrkB 信号系统差异基因表达并对差异基因进行关键靶点再验证，揭示电针大肠俞募穴双向肠道动力的分子机制。

The prevalence of functional bowel disorders ranges from 30% to 50%,and motility disorder is the basis. The responder rate of acupuncture for this condition is 80%-95%, and acupuncture is effective for improving disorder of bowel motility.We found that acupuncture at Shu-Mu points of large intestine is effective for both diarrhea and constipation. Moreover, we found the characteristics of cerebral response to this effect. Now what is the mechanism of this phenomenon? We hypothesized that electro-acupuncture at Shu-Mu points of large intestine improve bowel disoder through brain-gut-acupoint interaction,when motility is hypractive,it may work through reducing the expression of BDNF in colonic submucosal plexus, while enhancing BDNF in hippocampus thus inhibiting the BDNF-TrkB signal system; but when motility is underpowered,it works conversely. We will use multiple technics, to analyze the difference in gene expression in hippocampus and colonic submuscosal plexus, and to reexamine key target of the difference gene expression, to reveal the mechanism of electro-acupuncture for relieving disorders of bowel motility.