妊娠期间，胎儿的发育及母亲的健康密切依赖于胎盘，它对妊娠妇女健康、胎儿发育、以及出生后远期发育健康都至关重要。复发流产和子痫前期等妊娠疾病的发生发展与胎盘发育不完善直接相关，然而相关的分子机制仍有待深入阐释。本课题将采用生物学、化学、临床医学等多学科交叉的研究策略，围绕滋养层细胞合体化、侵润分化和子宫螺旋动脉改建等胎盘发育的重要生理环节，系统研究滋养层细胞分化的关键调控信号通路及其生理调控机制，挖掘其异常调控与自发流产及子痫前期的细胞和分子关联，探寻妊娠疾病的治疗靶分子及早期预警生物标记物，探讨靶向胎盘的妊娠疾病的防治策略。相关研究对全面提高人类生殖健康水平具有深远的意义。

During pregnancy, fetal development and maternal health are determined by the placenta. The long-term well-beings of the mother and the child are also believed to be influenced by this organ. The occurrence and progress of pregnancy-associated diseases, mainly including recurrent spontaneous abortion (RSA) and preeclampsia (PE), are thought to be in direct association with the abnormalities in the placenta. However, the underlying mechanisms remain to be systematically elucidated. The present project will combine biological, chemical and clinical medicine approaches to dissect the regulatory mechanisms that govern the major physiological events of placental development, including trophoblast syncytialization, invasion and uterine vessel remodeling. We will explore the molecular basis of RSA and PE in association with the abnormal regulations in these events, aiming to find out the biomarkers that can be used for predicting and preventing the diseases by targeting the placenta. This study will provide deeper molecular understandings on the pregnancy diseases, and therefore contribute to the promotion of human reproductive health.