精准评价生物分子与代谢特征已成为肿瘤个体化诊疗和大数据医疗的重要机遇，而Warburg效应是肿瘤精准医疗最有价值的靶标之一，以18F-FDG PET为基础的分子影像技术则是切实有效的研究路径。课题组在18F-FDG PET/CT定量分析和细胞代谢流量分析技术的基础上，拟建立18F-FDG PET/CT联合应用动态核极化（DNP）MRS的高分辨多模态分子影像定量分析技术平台并评价其准确性，以期为肿瘤精准医疗提供客观可行的技术方案。课题组在Sirtuin家族、PKM2和LDHA等理论研究的基础上，提出PKM2/LDHA-SIRTs交互调节Warburg效应促进肿瘤发生发展的研究假说及潜在的干预靶点，以期为肿瘤精准医疗提供关键的理论依据。通过上述研究，阐述Warburg效应关键调控机制及建立高分辨多模态分子影像定量分析技术平台，为精准靶向肿瘤Warburg效应的临床转化奠定科学依据。

Precisely evaluating biological molecular and metabolic characteristics has become the important opportunities in personalized and big data medicine in cancer. Warburg effect is one of most valuable targets in precision medicine of cancer. 18F-FDG PET molecular imaging technology based on Warburg effect is the effective method can be used in precision medicine of cancer. On the basis of work about 18F-FDG PET/CT quantitative analysis and metabolic flux assay, we are going to set up the high resolution molecular imaging platform via combined 18F-FDG PET/CT with DNP MRS, which would be a feasible technical scheme for precision medicine of cancer. On the basis of work about Sirtuin family, PKM2, LDHA and others studies, we hypothesizes that PKM2/LDHA-SIRTs regulatory loop would be a pivotal mechanism in Warburg effect and tumorigenesis, which might provide key rationale for precision medicine of cancer. Through these studies, we would elaborate the underlying mechanisms of Warburg effect and set up a high resolution molecular imaging platform, which would provide key rationale for translational and clinical application of Warburg effect.