申请者是美国心脏病协会会员和美国糖尿病协会，美国德克萨斯A&M 大学农业与生命科学院，营养与食品科学研究室，终身副教授。主持美国NIH等重点课题5项（总经费190万美元）。主要学术成就：①首先发现并阐明，Forkhead转录因子FoxO蛋白在分子细胞和生化水平传导胰岛素信号，从而调节糖代谢基因表达的分子机制；②运用动物模型进一步证明，FoxO蛋白在胰岛素抵抗中的失调是诱发糖尿病的关键；③发现膜蛋白CAML在血管紧张素Ⅱ信号传导中的重要作用。本合作项目在双方前期研究基础上开展T型钙通道在2型糖尿病心肌细胞中的再表达及其作用机制的研究，并进一步研究FoxO对心肌细胞死亡基因表达调控的影响。通过本研究的开展，有望从新的角度揭示糖尿病心脏病的发生机制，并将为糖尿病心脏病的临床治疗及新药研制提供新的思路。

Applicant, Principal Investigator, Membership of American Heart Association and American Diabetes Association, Associate Professor(tenure),Department of Nutrition and Food Science ,College of Agriculture and Life Sciences,Texas A&M University , Presided over grants of the United States NIH (total funding $1,900,000). The main academic achievements: ① To discover and clarify first Forkhead transcription factor FoxO proteins at the cellular and biochemical levels of insulin signal transduction molecules and the molecular mechanisms which regulate glucose metabolism gene expression; ② To clarify FoxO protein is the key to induce diabetes in insulin resistance by he use of animal models ; ③ To find it is important of CAML membrane proteins in signal transduction of angiotensin Ⅱ. We carried out the re-expression and molecular mechanism of T-type calcium channel blockers in type 2 diabetic myocardial cells by the cooperation projects,it will be further elucidated the new pathogenesis of type 2 diabetic cardiomyopathy or heart failure, and to provide new ideas for the prevention and treatment of type 2 diabetic complications of cardiovascular.