恶性肿瘤是威胁人类健康的重大疾病，而肿瘤的转移及复发是目前导致肿瘤病人死亡的最主要原因。肿瘤干细胞、循环肿瘤细胞、巨噬细胞及肿瘤相关巨噬细胞，在肿瘤复发特别是转移中的作用是最重要的因素之一。. 本研究前期工作表明，巨噬细胞能够吞噬凋亡的肿瘤细胞，并能够将其遗传物质整合到自身的细胞核中。吞噬了肿瘤细胞的巨噬细胞具有了干细胞的特征，进而转移入血成为肿瘤复发的种子，为肿瘤细胞的转移提供了一个新的可能和抗肿瘤药物的作用靶点。. 本研究科学问题的提出以凋亡肿瘤细胞、肿瘤干细胞以及肿瘤相关巨噬细胞之间关系研究的为基础，目的在于发现或证明巨噬细胞在凋亡肿瘤细胞诱导的肿瘤干细胞的成瘤、侵袭及相关的因子表达在肿瘤转移中的作用及可能机制。我们的研究结果将对癌症的治疗及治疗策略的确定,具有重要的理论意义和实际应用价值。

Malignant tumor is a major threat to human health, and the recurrence and metastasis of tumor is the leading cause of death in cancer patients. Tumor stem cells, circulating tumor cells, macrophages and tumor associated macrophages, especially in tumor recurrence and metastasis is one of the most important factors.. The previous work of our research shows that macrophages phagocytosis of apoptotic tumor cells, and can be integrated into their own genetic material in the nucleus. Phagocytosis of the macrophages from tumor cells with the characteristics of stem cells, and then transferred into the blood to become the seeds of tumor recurrence, provides a new possibility for the metastasis of tumor cells and the new target for anticancer drugs.. Our scientific issue are base on the relationship between the apoptosis of tumor cells and tumor stem cells and tumor associated macrophages. The purpose of which is to found or proved macrophages in tumor cell apoptosis induced by tumor stem cells into tumor, invasion and related factor expression as in tumor metastasis effect and possible mechanism. The results of our study will strategy for cancer treatment and determination, has important theoretical significance and practical value.