长链非编码RNA (long non-coding RNA，lncRNA) 是一类长度大于200nt，但不能编码蛋白质的RNA。其表达或功能异常与胰腺癌的发生发展关系密切。本研究主要探讨位于lncRNA上的，尤其是lncRNA:miRNA结合区的基因遗传变异 (single nucleotide polymorphisms，SNPs)，是否可能通过改变lncRNA和/或miRNA功能来影响胰腺癌易感性。我们首先整合多种数据库信息，在全基因组范围筛选目标区域的SNPs。然后结合我们前期胰腺癌全基因组关联研究数据，筛选到90个潜在的关联SNPs，接下来扩大样本量验证其与中国人群胰腺癌风险的关系。最后通过一系列功能实验，探索这些遗传变异及所在lncRNA的潜在生物学机制。本研究将加深对lncRNA在胰腺癌发生发展中作用的认识，并为发现功能性遗传变异提供新的思路，为胰腺癌的精准防治提供依据。

Long non-coding RNA (lncRNA) refers to a diverse class of transcripts that are larger than 200 nucleotides and do not serve as templates for proteins. There is increasingly evidence that aberrant expression contribute to the initiation and development of many cancers including pancreatic cancer. Accordingly, we assume that the Single Nucleotide Polymorphisms (SNPs) in lncRNA，especially in lncRNA:miRNA binding regions, may be associated with the susceptibility to pancreatic cancer. In this study, we firstly utilized bioinformatics methods to integrate a variety of databases to identify SNPs in lncRNA:miRNA binding region. Then, on the basis of our original genome-wide association study (GWAS) data, we screened and found 90 candidate SNPs. Subsequently, we will carry out an independent case-control study to validate the association between these candidate SNPs and risk of pancreatic cancer. Finally, several biochemical assays will be conducted to verify the association and reveal the underlying biological mechanism. Our study will provide new ways to identify functional genetic polymorphisms and deepen our understanding of the role of lncRNA in the pancreatic cancer.