目前，在生物材料的基础研究和临床应用中,迫切需要多尺度、多模态生物成像与图像处理的新技术，以满足在细胞/组织/活体水平上实现原位、定量、高分辨地观察生物材料与机体的精细作用过程，进而阐述其生物作用机制。本项目拟发展基于同步辐射X射线的新型成像技术，构建基于X射线相干衍射和吸收的多尺度、多模态生物成像与图像处理技术。利用该成像技术的三维、高分辨、高衬度、原位、定量、多尺度成像等特点，以肿瘤治疗生物材料与生物体的相互作用为研究目标，分别从活体、组织及细胞水平上研究生物材料在肿瘤区域的分布和富集，生物材料对肿瘤组织和血管的渗透，生物材料在肿瘤细胞中的定位和药物释放，探索功能性生物材料在生物体内的给药作用机制，以期为新型肿瘤治疗生物材料的设计、构建和临床应用提供理论指导和技术支撑。希望通过本课题研究，推动新一代X射线成像技术在生命科学中的应用，促进我国生物材料基础研究和生物成像技术的交叉融合发展。

Multiscale, multimodal imaging and image processing technology of biomaterials are urgently needed in basic research and clinical applications, in order to achieve in-situ quantitative observation of interactions between biomaterials and organism in cell/tissue/body level, thus explaining its biological mechanism. The project intends to develop new X-ray imaging techniques based on synchrotron radiation, and to build multiscale multimodal imaging and image processing system based on X-ray diffraction and absorption. By using of the technical characteristics of three-dimensional, high-resolution, high-contrast, in-situ, quantitative, multiscale imaging, we will study the interactions between organism and biomaterials for cancer treatment. In the different levels of body, tissue and cell, investigations will be conducted in following aspects: distribution of biomaterials in tumor areas; permeability of biomaterials in tumor tissues and vessels; location of biomaterials in tumor cells and the drug release. Subsequently, we will explore the mechanism of action of functional biomaterials in organism, in order to provide theoretical guidance and technical support for design and clinical applications of new biomaterials. This work will not only promote applications of new X-ray imaging techniques in life sciences, but also help to develop the cross-discipline between biological materials and biological imaging technology.