申请人从临床视角出发，一直专注于冠心病事件链机制及干预的转化医学研究，在4项国家自然基金连续资助下，构建了易损斑块冠脉影像检测与心肌组织灌注活体评价平台，创新提出血管易损性与心肌易损性的特殊关联，并聚焦代谢性核受体网络在冠心病事件链中作用及调控，发现代谢性核受体网络失衡是诱发冠心病事件链的重要机制，提出冠心病事件链干预的新靶点。共发表SCI论著55篇，近5年以通讯或第一作者（含共同）在JACC、EHJ等期刊发表23篇(总IF=135.7，平均IF=5.9，其中4篇IF>10，唯一通讯8篇)，并写入《心血管内科学教科书：Braunwald心脏病学(第10版)》和《中国急性ST段抬高心肌梗死PCI专家共识》等指南。申请人长期工作已形成独立稳定的研究体系，拟进一步对代谢性核受体在冠心病事件链中作用进行深入研究。

The applicant’s research has focused on the coronary artery disease continuum, from its underlying mechanisms to clinical interventions. With the sustained financial support from the Natural Science Foundation of China, the applicant’s systematic research has led to: 1) the characterization of an internal link between vulnerable vessel and vulnerable myocardium, by establishing a novel evaluation platform for in vivo characterization of vulnerable coronary plaques and quantitative assessment of myocardial perfusion; and 2) the discovery of several nuclear receptors as novel potential therapeutic targets for coronary artery disease, by providing novel insights into the role of metabolic nuclear receptors in the coronary artery disease continuum. The applicant’s research has been the subject of 55 original articles in international peer-reviewed journals, with 23 articles as first or corresponding author (4 paper IF>10) during the past 5 years, and cited in “Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine (10th edition)” and in the “Chinese Expert Consensus Statement on the management of patients with acute STEMI undergoing percutaneous coronary intervention”. The current application extents his previous observation and focus on the mechanism and intervention of coronary event continuum.