朝鲜淫羊藿（Epimedium koreanum Nakai）为中药淫羊藿药材主要来源之一，为大宗常用中药材，临床及保健品市场需求量大。课题组前期的研究发现目前市售的大部分朝鲜淫羊藿药材中淫羊藿苷含量不符合药典标准，而适当的高温干燥可以显著提高淫羊藿苷等多种异戊烯基黄酮类成分的含量，可望替代传统阴干和晒干方式。但是在高温干燥过程中，各成分转化的机理如何，高温干燥后对药材的药效及在体内的代谢情况有哪些影响？还不清楚。基于此，本课题组将首先采用HPLC及HPLC-MS等分析方法对不同方法，温度和时间干燥条件获得的朝鲜淫羊藿药材与传统干燥方法得到的药材进行全面的化学成分的定量定性分析。进而联合代谢组学，药效学和化学指纹图谱研究对传统干燥和高温干燥后的药材进行对比评价，综合实验数据探究朝鲜淫羊藿药材干燥机制。课题可以为阐明朝鲜淫羊藿药材干燥机理，优化加工方法，提升药材品质提供科学依据。

Epimedium koreanum Nakai is commonly used as a traditional Chinese medicine, which is one of the aerial parts of four sepcies as the official source for using Herba Epimedii in 2015 Chinese Pharmacopoeia. It is widely used clinically and being in great demand. However, our previous studies have shown that the icarrin content of mang of Epimedium koreanum was low and cannot reach to the standard of the Chinese Pharmacopoeia. Further work have found that proper high-temperature drying can improve the content of icarrin and other prenylated flavonoids. However, the mechanism of the transformation of the ingredient, the change of efficacy and metabolism in vivo after high-temperature drying is not clear. Therefore, we will compare the difference between the method of proper high-temperature drying and the traditional drying method with modern analyzing method, as well as metabonomic and fingerprints correlated with pharmacodynamics. This research will provide scientific evidence of the compositions’change mechanism of dying of Epimedium koreanum. Moreover, it can also provide guidelines to optimize processing of the other traditional Chinese medicines.