微动脉性脑病一直是研究热点，最新研究证实高等级的基底核区血管周围间隙(BG-PVS)和半卵圆中心血管周围间隙（CSO-PVS）与微动脉性脑病关系密切；然而，脑微静脉的正常结构和变异以及微静脉性脑病的研究非常匮乏。磁敏感加权成像(SWI)是一种新的MRI成像技术，对静脉血管有特殊敏感性，可检测到小于一个体素(200～300μm)的微静脉结构。本研究采用优化的SWI成像技术和3D-Doctor、Mimics等图像工作站及后处理软件，获取大脑髓质静脉的SWI图像数据，分析与探索感兴趣区髓质半卵圆中心区及基底核区的微静脉网络的走向、属支、分布密度、面积、引流和静脉间的吻合或交通等规律，并探索150μm以下的微静脉构建的可行性，为微静脉性脑病的研究（如微静脉出血和急性脑梗死病人髓质静脉改变等）以及高等级BG-PVS和CSO-PVS是否导致髓质静脉异常改变的研究提供科学依据。

Scholars have focused on arteriole encephalopathy for a long time and up-to-date it is demonstrated that both high degree of basal ganglia-preivascular spaces(BG-PVS) and centrum semiovale-preivascular spaces(CSO-PVS）were associated with it. However, the researches about the micro vein encephalopathy, the normal anatomical data, variation of the micro medullary veins are very scarce, and no complete data for reference. Susceptibility-weighted imaging(SWI ) is a new MR technique, which has special sensitivity to veins. It can detect less than an individual element of the venule (200～300μm). We obtain the data of micro medullary veins by using SWI and the 3D-Doctor, Mimics Workstation and we focus on the micro medullary veins in the centrum semiovale and basal ganglia regions, including venous networks, courses, tributaries, density and acreage of distribution, anastomosis and communication, and more, explore the possibility of the method of small vein less than 150 μm. As result, provide reference and guidance for the research of micro vein encephalopathy (e.g.micro venous bleeding and the abnormal medullary veins in acute cerebral infarct patients) and both high degree of BG-PVS and CSO-PVS are associated with the variation of micro medullary veins.