“逢子必炒”是长期的临床用药实践总结出的传统中药炮制理论，是对“种子”类中药炮制方法的简单概括，意即“种子”类中药均要通过“炒”才可入药，在中药炮制实践中具有一定的指导意义。但是，在中药炮制学科中，很多与之类似理论由于缺少现代科学依据的支持，致使其指导作用具有诸多局限性，进而制约了整个学科的发展。为此，本项目选取具有一定研究基础的“逢子必炒”理论为切入点，采用现代科学方法，为其寻找现代科学依据。选择具有代表性的5 种“种子”类中药：沙苑子、葶苈子、王不留行、决明子、蔓荆子等作为研究对象，以其水煎液中能够入血的多种成分作为评价指标，在化学成分研究的基础上， 对比分析种子类中药炮制前后药效成分的变化、溶出率的异同、生物利用度的差异、超微组织结构特征以及炮制过程中酶的作用等，并依据这些信息，应用统计学方法综合分析，揭示“逢子必炒”现代科学内涵。

“FengZiBiChao”, is traditional Chinese medicine theory about processing, which is summarized through long-term clinical practice. There is no doubt that the theory has certain guiding significance on the practice of TCM processing. However, it’s easily found that many such theories has their limits in the process of guiding practice because of lack of the support from modern science, thus restricting the development of entire discipline. In view of this, five representative Chinese material medicas are selected as object of study, including Semen Astragali Complanati, Semen Lepidii, Semen Vaccariae, Semen Cassiae, Fructus Viticis. Their water extract’s chemical components which can be absorbed into the bloodstream are chosen as evaluation index. Based on the study of chemical components, the changes of various indexes of the seeds before and after processing are contrasted and analyzed, such as the change of effective components, the discrepancy of dissolution rate, the difference of bioavailability, the feature of ultrastructure , the effect of enzymes during the course of processing, etc. According to information obtained above, statistical methods are adopted to conduct comprehensive analysis in order to reveal the modern scientific connotation of “FengZiBiChao” theory.