到目前为止，利用多肽分子探针针对炎癌转化调控分子网络的监测仍是一个巨大的挑战。本项目尝试采用跨键能量转移（TBET）机理来设计针对活性氧（ROS）的荧光探针，监测炎症及癌症中ROS的含量，了解炎癌转化中ROS含量的变化，同时将荧光分子连接到多肽上，创建高特异性的多肽分子探针，期望实现对ROS的实时动态监测，为炎癌转化及癌症的早期诊断提供相关的理论指导。

By far, it is a great challenge for real-time monitoring the transformation of the nonresolving inflammation to cancer. We try to design novel fluorescence probes based on TBET to monitor the levels of ROS both in vitro and in vivo, which may help us understand the roles of ROS play in inflammation and cancer. Meanwhile, we will also introduce the specific sequences into the probes, and this will further provide theoretical guidance for us to understand the transformation of the nonresolving inflammation to cancer and the early diagnosis of liver cancer.