注意缺陷多动障碍（ADHD）是儿童时期常见的行为障碍。研究发现约有70%的患儿症状持续到青春期，30%的患儿症状可持续到成年期，并与成年后吸烟、酗酒、反社会行为、甚至违法犯罪有密切关系，严重影响儿童的身心健康和学习生活，给家庭社会造成较大的影响和危害，故ADHD在有关儿童时期心理障碍的研究领域中越来越引起广泛重视。.ADHD病因及发病机制复杂，涉及多种理论和学说，而每一理论或学说均有其分子基础，因此从微观水平探讨其功能变化可能有助于解释ADHD的病因与机制。由于以人体为研究对象进行ADHD精神症状或行为方面的研究存在较多限制，如伦理学不允许应用有创伤性的操作来采集脑组织样本，难以真正实现ADHD分子机制研究等。随着ADHD动物模型的建立，克服了以人体为研究对象的局限性，从而使得运用动物模型，结合行为科学、各种分子生物学技术来阐明ADHD的病因和发病机制成为可能。.本次发言将从“动物模型的优势”，“目前建立的ADHD动物模型”，“ADHD动物模型的行为学检测”，“利用现代分子生物学技术结合动物模型探讨ADHD病因及发病机制的研究模式”四个方面阐述“动物模型在注意缺陷多动障碍发病机制研究中

Attention deficit hyperactivity disorder (ADHD) is a common behavioral disorder in childhood. The was found that about 70% of the children's symptoms continued to adolescence, 30% continued to adulthood, and ADHD is closely related to smoking, alcohol abuse, antisocial behavior, and even illegal crimes, which seriously affect children's physical and mental health and learning..The etiology and pathogenesis of ADHD are complex, which involves many theories, and each theory has its molecular basis, so it may be helpful to explain the cause and mechanism of ADHD from the microscopic level. Since many limitations of the human body as the research object to carry on the research on the ADHD mental or the behavior symptom, such as ethics does not allow the application to collect brain tissue sample, thus it is difficult to realize the ADHD molecular mechanism. With the establishment of ADHD animal model, it overcomes the limitations of human body as the object, which makes it possible to use the animal models, combined with behavioral science, a variety of molecular biology techniques to clarify the cause and pathogenesis of ADHD..This presentation includes four departments, "the advantages of the animal models ", “the animal models of ADHD”, "the behavior tests of the animal model of ADHD", " research on pathogenesis of ADHD by using of modern molecular biology techniques combined with animal models " to confirm the role of animal models in the pathogenesis of ADHD.

注意缺陷多动障碍（ADHD）是儿童时期常见的行为障碍。研究发现约有70%的患儿症状持续到青春期，30%的患儿症状可持续到成年期，并与成年后吸烟、酗酒、反社会行为、甚至违法犯罪有密切关系，严重影响儿童的身心健康和学习生活，给家庭社会造成较大的影响和危害，故ADHD在有关儿童时期心理障碍的研究领域中越来越引起广泛重视。 ADHD病因及发病机制复杂，涉及多种理论和学说，而每一理论或学说均有其分子基础，因此从微观水平探讨其功能变化可能有助于解释ADHD的病因与机制。由于以人体为研究对象进行ADHD精神症状或行为方面的研究存在较多限制，如伦理学不允许应用有创伤性的操作来采集脑组织样本，难以真正实现ADHD分子机制研究等。随着ADHD动物模型的建立，克服了以人体为研究对象的局限性，从而使得运用动物模型，结合行为科学、各种分子生物学技术来阐明ADHD的病因和发病机制成为可能。 本次发言从“动物模型的优势”，“目前建立的ADHD动物模型”，“ADHD动物模型的行为学检测”，“利用现代分子生物学技术结合动物模型探讨ADHD病因及发病机制的研究模式”四个方面阐述“动物模型在注意缺陷多动障碍发病机制研究中的作用。