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大豆蛋白-磷脂酰胆碱纳米乳液的稳定机制及营养素运载代谢途径

大豆蛋白-磷脂酰胆碱纳米乳液的稳定机制及营养素运载代谢途径
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  • 批准号:31571876
  • 批准年度: 2015年
  • 学科分类:粮油食品(C200504) |
  • 项目负责人:李杨
  • 负责人职称:副教授
  • 依托单位:东北农业大学
  • 资助金额:60万元
  • 项目类别:面上项目
  • 研究期限:2016年01月01日 至 2019年12月31日
  • 中文关键词: 大豆蛋白;磷脂酰胆碱;营养素;运载;代谢
  • 英文关键词:protein ;phospholipids;nanoemulsion;stable mechanism ;delivery and metabolism

项目摘要

中文摘要

纳米乳液是指粒径在10~200nm之间的一种乳化运输体系,与一般乳液相比,纳米级的粒径赋予体系特殊的小尺寸、高表面活性和强吸附等特性,进而对体系的物理化学稳定性和所运载营养物质的体内吸收起到增强效果。本研究以大豆蛋白和磷脂酰胆碱创制的纳米乳液为研究对象,针对交互作用机理、界面吸附规律及稳定机制和运载代谢途径等研究盲点,采用“结构基础-功能表达-运载代谢”的研究理念,集成交叉界面化学、结构化学及生物化学等理论及技术手段,全面解析大豆蛋白-磷脂酰胆碱聚合结构特征与交互作用机理,明晰纳米微乳的界面吸附及稳定机理,诠释纳米乳液营养素的运载代谢机制,最终全面地揭示大豆蛋白-磷脂酰胆碱纳米微乳体系稳定机制及运载代谢途径,为建立安全、低成本、高稳定性并兼具卓越体内吸收性能的新型纳米食品加工技术提供理论基础。

英文摘要

Nanoemulsions are colloidal systems usually with the droplet sizes around 10 to 200 nm. The very small droplet size offers nanoemulsions various advantages for their applications, including high physical and chemical stability, high surface activity and strong adsorption characteristic, which further increase the bioavailability of lipophilic functional ingredients. The research object is soy protein-phosphatidylcholine nanoemulsion. The present project applies the concept of “structure basis-functional expression-delivery metabolism” and integrates the theory and technical methods of interface chemistry, structure chemistry and biochemistry. Through in-depth analysis the structural characteristics and as well as the interaction mechanisms of soy protein-phosphatidylcholine polymerization, the mechanisms of interfacial adsorption and the stability of soy protein-phosphatidylcholine nanoemulsion could be clarified, and the metabolism of nutrients within nanoemulsion could be interpreted, and the interaction between soy protein and phosphatidylcholine and as well as their contributions to interfacial absorption and the stability of nanoemulsion and the relationship among the structure of nanoemulsion, interfacial adsorption stability, delivery forms, and nutrients physiological activity expression could be revealed. Eventually, fully reveal the system stability mechanism of soy protein-phosphatidylcholine nanometer nanoemulsion and delivery mechanism and metabolic pathways, which will provide theoretical basis for developing safe, low-cost, high stability and good in vivo absorption, controlled release and targeting capabilities of new nano food processing technology.

评估说明

    国家自然科学基金项目“大豆蛋白-磷脂酰胆碱纳米乳液的稳定机制及营养素运载代谢途径”发布于爱科学iikx,并永久归类于相关科学基金导航中,仅供广大科研工作者查询、学习、选题参考。国科金是根据国家发展科学技术的方针、政策和规划,以及科学技术发展方向,面向全国资助基础研究和应用研究,发挥着促进我国基础研究源头创新的作用。国科金的真正价值在于它能否为科学进步和社会发展带来积极的影响。

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