菌群-宿主交互平衡为研究中医药整合调节作用提供了新策略。前一国家自然基金研究表明，加味人参乌梅汤对腹泻大鼠肠道菌群与宿主代谢表型共变效应具有调控作用，但机制未明。腹泻是水液代谢紊乱疾病，而肠道菌群对宿主水代谢平衡具有重要意义。加味人参乌梅汤是否通过调控菌群与宿主代谢流程中的水液代谢交互发挥益气生津止泻效应呢？新近研究表明，菌群与宿主交互共代谢产物GABAA-R信号通路是腹泻病水液代谢平衡调控的关键靶点和有效路径。据此提出“加味人参乌梅汤通过GABA能信号通路调控菌群-宿主代谢交互水平衡发挥其益气生津止泻作用”假说。课题整合运用肠道宏基因组学、代谢组学、信号通路基因芯片等研究策略和方法，从水液代谢平衡机制切入，在整体、细胞、分子和基因水平，探明加味人参乌梅汤通过GABA能信号通路对菌群-宿主代谢交互水平衡效应的整体调控作用机制，从“菌群-宿主交互”的角度进一步丰富中医药整体调整的科学内涵。

That bacteria-host interactions balance provides a new strategy for integrated regulation of traditional Chinese medicine. The completed National Natural Science Foundation study shows that modified Renshen Wumei decoction on diarrhea in rat intestinal flora effect together with host metabolic phenotype has a regulatory role, but its mechanism is unknown. Diarrhea is the disease of water metabolism imbalance, while the intestinal microflora has important significance to the host water metabolic balance. Whether modified Renshen Wumei decoction regulating the fluid interaction between the process of flora metabolism and host metabolism to exerts its fluid antidiarrheal effect or not? Recent ground-breaking advances show that flora GABAA-R signaling pathway interacts with the host a total of metabolites are diarrhea disease water metabolism regulation of key targets and a valid path. Accordingly hypothesized that "modified Renshen Wumei decoction regulating the covariant effect of the intestinal flora-host water metabolism interaction balance by GABA-signaling pathway to exerts its fluid antidiarrheal effect”. This subject used strategies and methods， such as intestinal metagenomics , NMR metabolomics, signaling pathway microarray, from the point of the balance of water metabolism mechanism，on the whole, cellular, molecular and gene level, to prove the overall regulation effect of modified Renshen Wumei decoction on the microflora - host water metabolism interactive balance covariation effect by GABA-signaling pathway, further more to enrich the scientific connotation of traditional Chinese medicine therapy with "bacteria group-host interactive".