银屑病是一种多基因遗传的、环境因素刺激诱导的免疫异常性慢性增生性皮肤病，固有免疫、适应性免疫及皮肤屏障相关基因在银屑病的发病中发挥重要的作用。银屑病中固有免疫如何影响适应性免疫应答并进而导致皮损发生的机制不明确。Sprouty 1 (SPRY1) 是一种富含半胱氨酸的蛋白质，我们的初步研究发现，在正常皮肤中，SPRY1位于表皮颗粒层；而在银屑病表皮中，SPRY1表达水平降低或缺失。而且，我们通过RNAseq发现，SPRY1与固有免疫相关分子密切相关。因此，为了进一步阐明SPRY1在银屑病皮肤固有免疫中的作用及机制，我们以银屑病皮损及SPRY1转基因和基因敲除小鼠为模型，探讨SPRY1在调节皮肤屏障功能基因、固有免疫分子、角质形成细胞分泌的细胞因子和趋化因子等方面的作用，明确SPRY1改变对固有免疫细胞趋化的影响；探索创伤、感染及咪喹莫特等诱发银屑病表型产生的新机制，发现治疗银屑病的新靶标。

Psoriasis is a common and clinically heterogeneous group of immune-mediated chronic proliferative skin diseases caused by genetic and environmental triggers. Innate immunity, adaptive immunity and skin barrier play crucial roles in the pathogenesis of psoriasis. However, how cutaneous innate immune sensing orchestrates adaptive immune responses is not defined. Sprouty 1 (SPRY1) is a cysteine-rich protein. Our immunoflurescent data has shown that in normal skin, SPRY1 localized in the epidermal granular layer. However, in psoriatic skin, SPRY1 is decreased or lost in the epidermis. Furthermore, SPRY1 was found to be closely associated with innate immune in skin defined by RNA sequencing (RNAseq). Therefore, to further clarify the role of SPRY1 in the innate immune of psoriasis, psoriatic lesional skin and SPRY1 transgenic mouse and knockout mouse were included to investigate the role of SPRY1 in the construction of skin barrier, regulation of innate immune and cytokines and chemokines secreted by epidermal keratinocytes. We further investigated the role of SPRY1 in the chemotaxis of innate immune cells in psoriasis and the induced psoriatic phenotype by wound, infection and imiquimod. Finally, a novel target for the therapy of psoriasis may be determined.