颌面部骨缺损是口腔重大疾病，其修复重建是口腔临床重点需求。颌骨具有复杂的三维多级结构，生物力学特性复杂且不同患者的骨组织缺损模式不同，现有的修复重建手段存在创伤大、精度差、难以快速恢复美观功能等重大缺陷。快速成型技术可以精密构建个体特异性骨修复体，但现有的快速成型颌骨修复体难以同时兼顾生物活性与生物力学相容性，难以实现早期功能重建且远期稳定性差。本课题基于前期颅颌面生物力学模型研究的基础，结合逆向工程技术、虚拟生物力学分析、显微结构优化，设计出符合生理应力分布特征的颌骨修复体多级结构，进一步突破跨尺度非均质颌骨修复材料一体化成型成性、表面改性等关键技术，构建具有高生物响应性和良好的生物力学适配性的仿生功能化颌骨修复体；研究结果将为颌面部个性化、快速修复提供依据。

In orthopedic, oral and maxillofacial surgery repairing large bone defects with predictable results is still a substantial challenge. The use of autografts remains the “gold standard” technique for bone defect repair, despite the disadvantages of donor site morbidity and limited availability. The rapid prototyping techniques, capable of precisely fabricating customized scaffolds, provide great potential for tissue regeneration. However, the dilemma in balancing bioactivity and biomechanical compatibility does impede their clinical application. Based on the essential geometry foundation of cranial and maxillofacial biomechanical model, this proposal aims to study the bottle-neck problems currently facing in establishing functional maxillofacial scaffolds with biomimetic multilevel structures with rapid prototyping techniques. Customization of both the external geometry and internal cellular architecture, and the material properties of the scaffolds will be achieved. The main focus is the development of novel osteogenic scaffolds which obviate the need of exogenously added growth factors/cytokines in bone tissue engineering. The scaffolds made of the bioactive bio-inorganic polymers or their composites with traditional bio-ceramics will fulfil both mechanical and physiological requirements for the intended biomedical applications.

本项目以正常颌骨应力分布为依据，设计出符合生理应力分布特征的颌骨修复体宏观结构和微观骨小梁结构。通过计算机辅助模型转化为切片数据文件，完成功能化颌骨修复体的任意复杂外形和内部多级微细结构的非均质模型设计，建立缺损部位数字化模型。结合逆向工程技术、虚拟生物力学分析、显微结构优化，设计出了仿生多级结构颌骨修复体，与颅颌面咬合生理应力分布适配；优化纳米钙磷陶瓷纤维材料的制备与表面改性技术，快速成型兼具生物活性与生物力学适配性、性能可调的新型仿生多级结构、功能化颌骨缺损修复体。发表核心期刊论文1篇，培养硕士研究生1名，1人晋升副教授。