本课题从肿瘤微环境调控肺癌“炎癌进程”的功能视角出发，以肺癌细胞与成纤维细胞的交互作用为研究切入点，采用临床样本结合肿瘤细胞与微环境基质细胞共培养体系，明确法尼酯X受体FXR促进成纤维细胞与肺癌细胞的交互作用，深入探讨具体的分子调控机制网络；在此基础上，同步拓展至肿瘤微环境中其他基质细胞（如巨噬细胞、树突状细胞等），全面剖析FXR调控肿瘤微环境在推动肺癌炎癌转变中的作用，深度理解FXR在肺癌发生发展中的作用本质。研究结果将有望对重新审视FXR在肿瘤发生发展中功能的认识意义重大，对靶向FXR、克服炎-癌转化的抗肿瘤策略提供重要依据；同时对FXR深入系统生物学功能的挖掘、对肺癌的早期干预、早期诊断、早期治疗也均具有重要的指导意义。

The inflammatory tumor microenvironment (TME) has become an important pathological feature of tumor development. This project is a new perspective on the interaction between stromal and cancer cell in lung cancer development by focusing on the cancer associated fibroblast, which is the major component of the tumor stroma and plays key role in lung cancer development. Using clinical samples and tumor microenvironment co-culture system, we will explore the potential role and mechanism of farnesoid X receptor (FXR) in fibroblast-tumor cells interaction induced lung process. Further, extending to other tumor microenvironment stromal cells (such as macrophages, dendritic cells etc.), a comprehensive analysis of the role of FXR in the regulation of inflammatory TME induced lung cancer transformation will be obtained. These findings are expected from new perspective to interpret the role of FXR in regulation of dynamic process of the transformation of inflammation to cancer, especially via modulating stroma cells-tumor cells interaction. Our study has great significance for re-examine the function of FXR in tumorigenesis.