乳房炎是奶牛的常见病，而内蒙古的牛奶产量居全国第一位，目前治疗奶牛乳房炎主要采用抗生素疗法。但是，随着抗生素在全球的控制使用，急需健康、无残留的奶牛乳房炎治疗方法。植物提取物由于来源广泛、无残留、无抗性等特点，将会作为替代抗生素被广泛使用。单宁作为植物的次生代谢产物，它具有抗菌、抗氧化、抗病毒等特征，已广泛应用于畜牧业生产上。红豆草在生长的各个阶段都含有丰富的单宁，且产量高、适应性强、适口性好，并在我区大面积种植。本项目拟利用我区丰富的红豆草牧草资源以及它本身含有的高浓度单宁，经提取、纯化后，通过建立小动物急、慢性炎症模型和免疫低下模型以及小鼠乳房炎模型，对单宁的抗炎免疫机制以及针对乳房炎的免疫调节作用进行研究,制定出一套合理的提取、纯化单宁的方案，指出单宁含量高的生长阶段及部位，明确它的抗炎免疫作用，为利用天然植物代谢产物替代抗生素治疗奶牛乳房炎做一定的理论依据和技术指导。

Cow mastitis is a common disease in dairy cattle, and milk production of Inner Mongolia is highest in China. Nowdays, antibiotic therpy is the most effective way in treating dairy cow mastitis. However, it becomes an inevitable to seeking for healthy antibiotic from plants, with antibiotic being controlled to use in the world. Plant extracts will be used widely as antibiotic'replacement. Secondary metabolites of plants, tannins, used in animal husbandry wildly, becausing of wide distribution and diverse characteristics including antibacterial, antioxidant, antiviral and so on. So it is becoming a new research hotspot. Sainfoin is known as its high yield, good adaptability to the environment and good palatability whether grass or hay. Rich tannins are including in sainfoin's various stages of growth. Sainfoin is planted in large area of Inner Mongolia. This project will be carried out in using of MengNong sainfoin. After extracting and purifying tannins, we will research on its anti-inflammatory action and immunomodulatory by making inflammation, immunosuppression and mastitis models, Develop a reasonable method of extracting and purifying tannins; Pointed out that in which growth stages and parts contains highest tannins; Clarify that anti-flammatory and immune action of tannins. It will provide some theoretical basis and technical guidance for treating cow mastitis.