“非专职免疫器官”的区域性免疫特征及其调节对于疾病的发生和发展有重要影响。Ⅰ型干扰素作为机体最重要的天然免疫效应分子，不仅具有高效的抗病毒活性，而且具有广泛的免疫调节作用。我们以前的研究发现，I型干扰素能够通过细胞因子IFN-I-IL27-IL10联合效应程序发挥有效的抗炎症作用。本项目拟以流感病毒感染为模型，通过研究细胞因子IFN-I-IL27-IL10联合效应程序对肺脏区域性免疫的影响，以及在流感发生与发展中所发挥的作用，揭示Ⅰ型干扰素调节肺脏区域免疫的分子机制。另外，我们也将研究流感病毒感染在肺脏诱导产生的I型干扰素等细胞因子对于肠道微生物菌群和区域性免疫以及肠道对其他外来病原体易感性的影响，阐明一种器官区域免疫之间相互影响和调节的新模式。这些研究不但会使我们对肺脏和肠道区域性免疫特征及天然免疫信号对机体区域性免疫的调节有更加深入的认识，也将为我们选择和设计新的疾病干预策略提供信息。

Regional immunity characteristics and its regulation of nonprofessional immune organs have an important impact on the occurrence and development of diseases. Type Ⅰinterferon(IFN-Ⅰ) is one of the most important effector molecular of innate immune response，it not only has a highly effective antiviral activity but also plays a critical role in immune regulation. Particularly, our previous studies have shown that IFN-Ⅰcan exert a anti-inflammatory effect by a IFN-I-IL27-IL10 gene program. In this study, we will use the influenza infection as a model to determine the role of the IFN-I anti-inflammatory gene program in the development of post-influenza secondary bacterial pneumonia，and reveal the molecular mechanisms involved in the regulation on lung regional immunity by IFN-l. Furthermore, we will determine if IFN-Ⅰ produced in the lung during influenza virus infection will affect bacterial growth and change microbiota in the gut，this will help us to understand the association of influenza infection with diseases in the gut. These studies will help us gain a better understanding of regional immunity characteristics in lung and gut, providing new theoretical basis for lung or gut diseases.