慢性阻塞性肺疾病是一种常见、多发的慢性呼吸系统疾病，遗传因素在其发病与进程中起重要作用。Brehm于2011年12月首次报道FGF7基因可能是COPD的易感基因。我们于2012年5月首次报道中国汉族人群FGF7基因的多态性与COPD的相关性。FGF7在COPD发病过程中作用及机制不清楚。本研究采取免疫组化、RT-PCR、ELISA和细胞免疫荧光等方法，通过（1）检测COPD患者肺组织及血浆中FGF7表达水平，探讨FGF7表达水平变化及与肺功能和气道重塑相关性。（2）通过原代气道上皮细胞研究FGF7在香烟提取物刺激下表达变化情况，FGF7通过调控ERK1/2通路对气道上皮细胞增殖的作用机制。（3）构建香烟诱导慢性阻塞性肺疾病动物模型，干扰FGF7在肺内的表达水平，明确FGF7在COPD气道重塑过程中的作用及机制，为COPD治疗和新药开发提供新靶点。

Chronic obstructive pulmonary disease (COPD) is a common chronic respiratory disease, and genetic factors play an important role in the pathogenesis of the process. In December 2011 ,Brehm have first reported that FGF7 gene maybe the susceptibility genes for COPD.We reported the correlationship of which FGF7 gene polymorphism with COPD in Chinese population in May 2012.Addition to affecting the development of pulmonary morphology, but also stimulating airway and alveolar epithelial cell proliferation specially,except for involving in pulmonary regeneration and repairation.While,if it has en effect in COPD pathogenesis and the mechanism remains unknow.In the reaserch,we will take the methods with immunohistochemistry, RT-PCR, ELISA and immunofluorescence.Firstly,Detecting FGF7 expression in plasma and lung tissue of COPD patient,to explore relationship which with spirometric and airway remode.Secondly,FGF7 expression,as well as the regulate mechanism of FGF7 by ERK1 / 2 pathway to airway epithelial cells under cigarette extract stimulation,which use parental pulmonary airway cell and passaged cell lines in vitro experimental study.Thirdly,Constructe a cigarette-induced animal model of COPD,as well as interfering with the expression levels in the pulmonary of FGF7, focusing on the role and mechanism of FGF7 in airway remodeling,thus determining the role and mechanism in airway remodeling in COPD,which provide new targets for COPD therapy and drug development.