围绕“血管组织修复再生与稳态调控”关键科学问题，综合运用工程材料科学原理和技术手段，从材料空间结构设计、仿生功能表/界面构建、活性因子装载与可控传输三个方面开展研究工作。成功构建出具有抗凝血和促进内皮快速形成双重功能的人工血管；通过结构优化解决了人工血管“细胞化”瓶颈问题，有效改善了血管组织再生和功能稳态；创新性制备出具有“酶控”一氧化氮（NO）释放功能的新型生物材料，实现了NO的“可控”、“按需”传输，对于疾病状态下血管组织修复再生以及血管稳态的调控具有重要作用。目前，申请人发表SCI收录论文40余篇，累计影响因子>170。论文被包括Sci Transl Med等权威期刊引用或评述>500次。近五年，以通讯/第一作者发表论文15篇（IF>5的文章11篇，包括Biomaterials（IF=8.312）四篇；J Control Release（IF=7.261）两篇）。申请发明专利两项。

Focusing on the “Vascular regeneration and homeostasis” key scientific problem, we make full use of theory and technology of materials science and engineering to perform research work in three aspects: 1) structure design and optimization; 2) biomimetic surface and interface functionalization; 3) loading and controlled delivery of bioactive molecules. Up to now, we have successfully fabricated a kind of vascular grafts with dual surface functions of anti-thrombogenicity and rapid endothelialization. Through structural optimization, the problem of limited cellularization in vascular grafts has been effectively resolved, and thus the vascular tissue regeneration as well as the functional homeostasis has been improved. In addition, novel biomaterials with enzyme-controlled nitric oxide (NO) releasing property has been successfully prepared, therefore controllable and on-demand NO delivery has been realized, which is very important for the regeneration of vascular tissue and regulation of vascular homeostasis, especially in aged/diseased model. The applicant has authored over 40 SCI-indexed papers with total IF>170, which have been cited by leading journals including Sci Transl Med for more than 500 times. In recent 5 years, he has published 17 papers as first/corresponding author (11 papers with IF>5, including Biomaterials (4), J Control Release (2)). As a main inventor, he has also applied for 2 Chinese patents.