临床上神经损伤较常见，所造成的相应支配区域功能丧失给病人带来极大的生活不便和心理痛苦，其治疗修复一直是神经外科领域备受关注的热点。本课题组前期研究工作中采用显微外科技术结合自体腓肠神经移植物行面神经和舌下神经端-端吻合术修复大鼠完全性面瘫，结果发现舌下神经可完全替代面神经支配面部肌肉。说明神经可异位支配，并存在中枢可塑性。为了进一步研究神经异位支配的发生机制，本研究拟在上述前期工作的基础上，应用功能核磁共振技术观察在舌下神经电刺激干预下脑皮层相关运动区及皮层下神经核团激活特性，明确舌下神经异位支配中枢运动整合的传导通路,为深入开展脑功能研究及明确中枢神经系统的可塑性奠定理论基础。

The nerve injury is very common in clinical,whic leads to the loss of function in corresponding control area. Neurosurgery have been seeking methods to treat nerve injury. Our preliminary study had proven that facial-hypoglossal anastomosis combinating autologous predegeneration nerve graft could effectively and quickly repair permanent facial palsy in rats. This suggests that muscle can be dominated by ectopic nerve and the plasticity in central nervous system is available. To further investigate the happen mechanism , this study will use fMRI technique combinating hypoglossal nerve electrical stimulation to figure out the characteristics of related cortical activate area and subcortical neuron movement. The purpose of this research is to clarify the possibility of hypoglossal instead of facial nerve in treating facial palsy and the plasticity of central nervous system.

本课题组前期研究工作中发现，舌下神经通过神经移植物桥接面神经可促进大鼠面瘫恢复。本研究在此基础上，通过鼻尖偏离指数测定、运动诱发电位、逆行示踪、电镜新生髓鞘计算及动物功能核磁共振技术，拟证明在舌下神经电刺激干预下脑皮层相关运动区及皮层下神经核团激活特性。结果显示，舌下神经电刺激可促进大鼠完全性面瘫恢复。但由于功能核磁共振数据无分析软件，目前还不能确定“异位神经支配存在中枢可塑性”的结论。