轻度脑外伤（mTBI）及其引发的应激功能障碍（PTSD）有较高发生率，但因缺乏影像学阳性所见和神经功能定位体征，使其诊断具有主观性和不确定性，客观检查手段已成为研究热点。本项目拟在我们前期工作基础上，以mTBI及mTBI继发PTSD病人为研究对象，以中度TBI、PTSD病人及健康人作对照，应用事件相关电位（ERP）、脑磁共振影像数据时空分析及分子生物学技术完成下列研究：①mTBI后额叶皮质、海马、杏仁核、胼胝体等脑区容积的动态变化；②上述结构容积动态变化与PTSD易感性的关系；③mTBI及PTSD的ERP及影像学特征、脑区溯源与脑网络调节变化；④外周血中mTBI及PTSD的遗传学及表观遗传学特异性生物标记物及调控路径。最终目标是建立具有转化医学意义的mTBI及PTSD客观检查手段，并探索其脑功能网络调节变化机制及分子调控机制，为mTBI及PTSD的临床诊断、预后评估及法医司法鉴定提供依据。

The incidence of mild traumatic brain injury (mTBI) and posttraumatic stress disorder (PTSD) are high but the diagnosis is uncertain and subjective due to the lack of positive radiographic findings and absence of clinical neurological signs, and therefore, the exploring of objective examination means has become a hot research topic. Based on our previous work, we are going to completed the following researches on mTBI and mTBI induced PTSD patients with the application of event related potentials (ERP), brain magnetic resonance imaging data analysis and molecular biology technology: ① dynamic volume changes of frontal cortex, hippocampus, amygdala, and corpus callosum after mTBI; ② the relationship between the dynamic changes of structure volume and PTSD; ③ the characteristics of ERP components and imaging brain regions in mTBI and PTSD patients, and tracing the brain network adjustment; ④ specific biological markers of mTBI and PTSD in the peripheral blood of the patients and the mutual regulation of these bio-markers. The ultimate goal of this project is to establish objective examination means of mTBI and mTBI induced PTSD for clinical diagnosis, prognosis and forensic applications, and to explore the brain functional network and molecular regulation mechanism after TBI and PTSD.