溃疡性结肠炎（UC）是一种难治性疾病，晚近发现维生素D与UC发病密切相关。前期研究结果提示UC大鼠的血清和结肠组织中维生素D活化形式的1,25-(OH)2-D3和维生素D受体（VDR）浓度降低，针灸能调控UC大鼠结肠组织VDR及结肠炎患者结肠组织中的抗菌肽（β-防御素和Reg家族）的表达。本项目拟从VDR信号通路、肠道抗菌肽与UC结肠黏膜炎症相关性为切入点，应用组织形态学、分子生物学、基因敲除和同重同位素相对与绝对定量等技术与方法，旨在从VDR信号通路中的初始应答基因的沉默，以及与溃疡性结肠炎结肠黏膜IL-22/Reg轴的异常激活的双向调控角度，阐释艾灸调控UC结肠黏膜VDR及抗菌肽（β-防御素和Reg家族）表达的机制，拟证实艾灸调节Th细胞分化、纠正溃疡性结肠炎结肠黏膜病变，以达到艾灸治疗和阻遏溃疡性结肠炎结肠黏膜炎症之目的，以期为艾灸治疗溃疡性结肠炎及临床应用提供实验资料和科学依据。

Ulcerative colitis (UC) is a steroid-refractory disease, and the pathogenesis of UC is closely related to vitamin D. Preliminary studies suggested that serum 1,25-OH)2-D3 and VDR concentrations were decreased in the UC group from the normal group. Acupuncture and moxibustion treatment regulated VDR signaling of colon tissue in UC rats and β-defensin peptides and REGs of colon tissue in patients with colitis. Based on the effectiveness of acupuncture and moxibustion on UC, this study further using histology, cytology, molecular biology and iTRAQ technologies and methods, to confirm that VDR signaling plays a role in UC mucosa injury and immune imbalance, to investigate regulation of the intestinal antibacterial peptide expression in UC, and to explore the role of IL-22/REGs axis in UC. To further explaining the effect mechanism of moxibustion on UC, and providing scientific evidence for acupuncture and moxibustion in the treatment of UC.