化疗相关认知障碍（Chemotherapy-induced cognitive impairment，CICI）是指癌症患者在化疗过程中或化疗后所致的认知功能损害。化疗延长了乳腺癌患者的生存期，但CICI却严重影响了其生活质量。目前，有关乳腺癌CICI的研究发现其存在显著的异质性，而乳腺癌可通过其基因表达谱的不同区分不同分子亚型。迄今，不同分子亚型乳腺癌的CICI特征及其发生机制尚不明确。本研究基于乳腺癌CICI存在异质性的假设，以不同分子亚型的乳腺癌化疗患者为研究对象，通过对其APOE、COMT基因多态性的监测，认知神经心理学测查、事件相关电位及脑功能成像的研究，探索基于不同分子亚型乳腺癌的APOE、COMT基因表达的多态性；ERP中N400和P600的变化及前额叶、海马等脑区功能及脑网络功能连接改变的差异；从而揭示乳腺癌CICI发生的特异性生物学机制，为临床早期识别及干预提供理论依据。

Chemotherapy-induced cognitive impairment(CICI)，refer to the problems that cancer survivors experience with their memory, attention and information processing speed during or after completing chemotherapy.Chemotherapy is widely used as an adjuvant to treatment breast cancer patients,and their survival time has been improved .While these symptoms may serious influence their quality of life (QOL).Cognitive changes associated with cancer treatments have become an increasing concern now.Breast cancer is a highly heterogeneous tumor,and can be classified into different molecular subtype based on multiple gene exPression. Until now, the characteristics and mechanism of CICI on different molecular subtypes of breast cancer patients are still not clear.The study based on the hypothesis that CICI in breast cancer patients exists heterogeneity. We investigated four kind of breast cancer patients based on their different molecular subtypes who undergo chemotherapy through the research from neuropsychological, genetic, ERP and Fmri studies.Genetic factors such as apolipoproteinE (APOE) and catechol-O-methyltransferase (COMT) have been associated with CICI. In the study, COMT and APOE gene expression of polymorphism,N400 and P600 changes in ERP and the function of prefrontal, hippocampus and other brain areas or brain network changes are all investigated. We try to clarify the specific mechanisms of CICI based on different molecular subtypes of breast cancer, and provide the theoretical basis for early identification and intervention of CICI in breast cancer patients.

化疗相关认知障碍（Chemotherapy-induced cognitive impairment，CICI）是指癌症患者在化疗过程中或化疗后所致的认知功能损害。化疗延长了乳腺癌患者的生存期，但CICI却严重影响了其生活质量。目前，有关乳腺癌CICI的研究发现其存在显著的异质性，而乳腺癌可通过其基因表达谱的不同区分不同分子亚型。迄今，不同分子亚型乳腺癌的CICI特征及其发生机制尚不明确。本研究基于乳腺癌CICI存在异质性的假设，以不同分子亚型的乳腺癌化疗患者为研究对象，通过对其APOE、COMT基因多态性的监测，认知神经心理学测查、事件相关电位及脑功能成像的研究，探索基于不同分子亚型乳腺癌的APOE、COMT基因表达的多态性；ERP中不同成分的变化及前额叶、海马等脑区功能及脑网络功能连接改变的差异；从而揭示乳腺癌CICI发生的特异性生物学机制，为临床早期识别及干预提供理论依据。