中文摘要
肿瘤是目前危害人类健康最严重的疾病之一，早期诊断与治疗是提高患者生存质量和治愈率的关键，而传统的CT和MRI造影剂却难以同时实现早期诊断与治疗的统一，多功能、多模态高效纳米材料MRI/CT造影剂的研究与开发是实现肿瘤早期诊断与治疗的出路。通过研究镧系及贵金属纳米颗粒与镧系元素离子以及钇、锰等离子的螯合方法，寻找温和、稳定且易于控制产量的连接途径，探讨多种离子功能化的多种金属纳米体系的质子驰豫效能及其对RF的升温速率效率，并在金属纳米颗粒被动靶向聚集作用下，通过复合纳米结构增强的MRI/CT造影实验和RF热损伤肿瘤细胞体外实验及动物实验，验证其作为MRI/CT高效造影剂和热损伤治疗癌症介质的可能性，从而制备集肿瘤早期诊断与RF热损伤治疗功能于一体的多功能复合生物纳米材料，为肿瘤早期诊断和RF热损伤治疗提供理论依据。
英文摘要
Cancer is one of the most serious diseases to jeopardize human health at present, early diagnosis and treatment of cancer is the key to improve the quality of patient survival and cure rates, and that, conventional CT and MRI contrast agents are difficult to achieve early diagnosis and treatment simultaneously, the study and development of multi-functional, multi-modal and high efficient nano-material MRI/CT contrast agents is the way out of the tumor early diagnosis and treatment. Through the research of chelating methods of the lanthanide and precious metal nano-particles with the lanthanide ions, yttrium and manganese ions, looking for a mild, stable and easy control output connection pathway, to explore the proton relaxivity efficiency of the multiple ionic functionallised, multiple metal nano-systems and their heating rate to the RF, through the studies of composite nanostructure enhanced MRI / CT imaging and the tumor cell's RF heat damage in vitro by the passive targeted aggregation ability of metal nanoparticles, to verify the possibility of these nanostructures as efficient MRI / CT contrast agents and the media of thermal damage to treat cancer, and thus to prepared multi-functionallised biological nanomaterials with the abilities of early diagnosis and RF thermal injury treatment of tumor in-one, to provide a theoretical basis for cancer early diagnosis and treatment of RF thermal damage.
结题摘要
肿瘤是目前危害人类健康最严重的疾病之一，早期诊断与治疗是提高患者生存质量和治愈率的关键，而传统的CT和MRI造影剂却难以同时实现早期诊断与治疗的统一，多功能、多模态高效纳米材料MRI/CT造影剂的研究与开发是实现肿瘤早期诊断与治疗的出路。通过研究镧系及贵金属纳米颗粒与镧系元素离子以及钇、锰等离子的螯合方法，寻找温和、稳定且易于控制产量的连接途径，探讨多种离子功能化的多种金属纳米体系的质子驰豫效能及其对RF的升温速率效率，并在金属纳米颗粒被动靶向聚集作用下，通过复合纳米结构增强的MRI/CT造影实验和RF热损伤肿瘤细胞体外实验及动物实验，验证其作为MRI/CT高效造影剂和热损伤治疗癌症介质的可能性，从而制备集肿瘤早期诊断与RF热损伤治疗功能于一体的多功能复合生物纳米材料，为肿瘤早期诊断和RF热损伤治疗提供理论依据。