中文摘要
青少年特发性脊柱侧凸（AIS）是一类严重影响人类生活质量的脊柱畸形，其生物力学改变情况复杂，但尚无公认合理的模型加以模拟，是临床上仍待解决的问题。目前常规的后路三维矫形内固定融合技术，对于部分仍具强生长潜能的AIS患者既限制了脊柱的进一步生长，又存在着"曲轴现象"而导致矫形失败的可能。非融合的矫形内固定技术以其保留脊柱继续生长、减少因融合而导致失败的特点，成为近年来国际上关注的热点。本课题应用螺旋CT对AIS患者进行连续超薄扫描重建脊柱侧凸三维形态，并通过有限元分析的方法建立数字模型加以模拟，分析研究椎体间应力、位移和形变等力学参数改变，获得较完整的AIS脊柱侧凸生物力学数据库；进一步应用于一种具有原创知识产权的可自动向远端滑动的新型非融合矫形内固定系统的力学测试和初步验证。在阐明AIS生物力学和运动学变化规律的同时，也将为上述非融合内固定技术的应用及器械研制提供重要的生物力学依据。
英文摘要
Adolescent idiopathic scoliosis (AIS) is a kind of spinal deformity which seriously influences the quality of life. Its biomechanical change is complex, but there is no recognized reasonable model to be simulated, so it is a very difficult clinical problem. At present the conventional posterior 3-d orthopedic internal fixation fusion technology, for some AIS patients who still has strong growth potential, not only limits the further growth of the spine, but also makes the failed orthopedics possible as the "crank phenomenon". The non-fusion internal fixation technology which is characterized by keeping the spine growing and reducing failure caused by fusion, has recently been paid close international attention.The study reconstruct the scoliosis 3-d form using spiral CT in patients with AIS continuous ultrathin scanning , establish a digital model to simulate with the finite element analysis method , analysis and study intervertebral bodies stress, displacement, deformation and mechanical parameters' changes, and get a complete AIS biomechanics database; Furthermore, apply to a kind of new non fusion in orthopedic fixed system mechanical test and preliminary validation which has original intellectual property , can automatically slide to the distal end. We clarify the AIS biological mechanics and kinematics change rule, meanwhile it will provide important biomechanical basis of application of fixed and equipment development of the internal fixation nonfusion technology.
结题摘要
青少年特发性脊柱侧凸（AIS）是一类严重影响人类生活质量的脊柱畸形，其生物力学改变情况复杂，但尚无公认合理的模型加以模拟，是临床上仍待解决的问题。目前常规的后路三维矫形内固定融合技术，对于部分仍具强生长潜能的AIS患者既限制了脊柱的进一步生长，又存在着"曲轴现象"而导致矫形失败的可能。非融合的矫形内固定技术以其保留脊柱继续生长、减少因融合而导致失败的特点，成为近年来国际上关注的热点。本课题应用螺旋CT对AIS患者进行连续超薄扫描重建脊柱侧凸三维形态，并通过有限元分析的方法建立数字模型加以模拟，分析研究椎体间应力、位移和形变等力学参数改变，获得较完整的AIS脊柱侧凸生物力学数据库；进一步应用于一种具有原创知识产权的可自动向远端滑动的新型非融合矫形内固定系统的力学测试和初步验证。在阐明AIS生物力学和运动学变化规律的同时，也将为上述非融合内固定技术的应用及器械研制提供重要的生物力学依据。