This functional magnetic resonance imaging (fMRI) project is of great significance in future overweight and obesity studies. Obesity is a major health problem worldwide and acupuncture, which has been around for over 3000 years, has been shown to be an effective treatment modality for this condition. fMRI is useful for human brain mapping as shown in numerous studies. We are in the process of determining how certain acupuncture points can affect certain regions of the brain to control appetite and satiety. There are complex neurohormonal pathways that this project will hope to address in order to identify the mechanisms by which manual and electroacupuncture influences human neurophysiology. This study focuses on how certain acupoints and their sham counterparts, such as LI 4 (He Gu), LV 3 (Tai Chong), GV 3 (Yao Yang Guan), GV 4 (Ming Men), LI 10 (Shou San Li), ST 36 (Zu San Li), GB 34 (Yang Ling Quan), SP 9 (Yin Ling Quan) and SP 6 (San Yin Jiao), acutely have an effect on the satiety center, glucose metabolism, and core body temperature (basal metabolic rate (BMR)) in young (age 21-35 years), healthy, “regionally” overweight (Body mass index >18 to <30 kg/m2) Chinese males who have not been on a weight loss program for the past 3 months. Connectivity analysis will utilize the amygdala (AMY) and hypothalamus (HYP) as regions of interest (ROIs) in the discrete cosine transform and seed correlation analysis methods. This project, as well as other future studies, will be of great importance in helping understand how acupuncture can be a safe, inexpensive, and highly effective treatment modality for one of the world’s most common detrimental diseases, obesity.