中文摘要
在国家自然科学基金重点项目基金的资助下,我们获得一些成果: (1) 探讨了Treg细胞在人葡萄膜炎发生中的作用，揭示出Treg细胞参与了人类葡萄膜炎发生，CD4+CD25highTreg细胞的紊乱是VKH综合征发生、慢性化及复发的重要机制。(2) 探讨了Treg细胞在实验性自身免疫性葡萄膜炎动物模型（EAU模型）中的作用，揭示出正常功能的Treg细胞是EAU迅速消退的重要机制。(3) 探讨了Treg细胞在ACAID形成中的作用，发现四群Treg细胞在ACAID形成中起重要作用，Treg细胞可诱导出抗原特异性的免疫耐受。(4) 探讨了多种免疫抑制剂对葡萄膜炎的治疗作用及可能机制，发现免疫抑制剂可通过抑制Th1（IFN-γ）细胞及Th17细胞（IL-17）而发挥对葡萄膜炎的治疗作用。(5)根据国际最新研究进展，我们拓展了原有的研究内容，其中包括葡萄膜炎发生机制、生物学标志、与葡萄膜炎发生相关的基因多态和葡萄膜炎的临床研究。发表SCI论文36篇，完成《葡萄膜炎诊断与治疗》专著1部。上述研究促进了我国葡萄膜炎的基础及临床研究，并炼造了一支国际上该领域中的重要研究团队。
英文摘要
Uveitis, a common causes leading to blindness worldwide, has been considered to be caused mainly by autoimmune response. The studies supported by Key Project of Natural Science Foundation focused on the role of regular T cells (Treg) in the development of uveitis and have gained the following achievements：(1) Our study revealed that Treg cells are involved in the development of uveitis. The disturbance of CD4+CD25high Treg in both frequency and function might be one of the most important mechanisms of the development, chronicity and recurrence of VKH disease. (2) Studies on Treg in a uveitis animal model, experimental autoimmune uveoretinitis (EAU), discovered that a significantly increased frequency and immunoregulatory action of CD4+CD25+ Treg cells is associated with the development and regression of EAU. (3) Concerning studies on anterior chamber associated immune deviation (ACAID), our results revealed that four populations of Treg cells were critical in the development of ACAID. Treg cells were found to be able to induce the antigen-specific immune tolerance. (4) We evaluated the outcomes of treatment with various immunosuppressive agents in uveitis and further investigated the possible mechanism involved. We found that immunosuppressive agents may exert their immunosuppressive role by downregulating Th1 a
结题摘要
在国家自然科学基金重点项目基金的资助下,我们获得一些成果: (1) 探讨了Treg细胞在人葡萄膜炎发生中的作用，揭示出Treg细胞参与了人类葡萄膜炎发生，CD4+CD25highTreg细胞的紊乱是VKH综合征发生、慢性化及复发的重要机制。(2) 探讨了Treg细胞在实验性自身免疫性葡萄膜炎动物模型（EAU模型）中的作用，揭示出正常功能的Treg细胞是EAU迅速消退的重要机制。(3) 探讨了Treg细胞在ACAID形成中的作用，发现四群Treg细胞在ACAID形成中起重要作用，Treg细胞可诱导出抗原特异性的免疫耐受。(4) 探讨了多种免疫抑制剂对葡萄膜炎的治疗作用及可能机制，发现免疫抑制剂可通过抑制Th1（IFN-γ）细胞及Th17细胞（IL-17）而发挥对葡萄膜炎的治疗作用。(5)根据国际最新研究进展，我们拓展了原有的研究内容，其中包括葡萄膜炎发生机制、生物学标志、与葡萄膜炎发生相关的基因多态和葡萄膜炎的临床研究。发表SCI论文36篇，完成《葡萄膜炎诊断与治疗》专著1部。上述研究促进了我国葡萄膜炎的基础及临床研究，并炼造了一支国际上该领域中的重要研究团队。