中文摘要
本项目应用"俞募配穴"(大肠俞、天枢) ，"合募配伍" (上巨虚、天枢)治疗溃疡性结肠炎，通过临床与动物实验研究，从信号传导及转录激活因子（STAT-3、STAT-4）信号转导角度，探讨溃疡性结肠炎Th1/Th2细胞极化的细胞内信号转导途径，以及针灸干预的信息传导机制，探讨艾灸经穴效应与 Th1/Th2细胞平衡的相关性，并分析部分相关特定穴的红外辐射特性。研究显示经穴配伍是影响经穴效应的重要因素，俞募配伍、合募配伍是治疗溃疡性结肠炎有效的经穴处方，合理的经穴配伍能够产生协同作用，针灸能够通过调节Th1/Th2细胞极化的细胞内信号转导途径及转录激活因子STAT-3和STAT-4，发挥对溃疡性结肠炎异常免疫功能状态的调节作用。患者特定穴红外光谱研究显示，上巨虚等特定穴在不同程度上都能反映溃疡性结肠炎患者一定的病理的信息。研究并阐释了艾灸治疗溃疡性肠炎效应与灸量有关。
英文摘要
This item is applying the TCM theory of "Shu matching Mu"(Dachangshu BL 25 and Tianshu ST 25) and "He matching Mu"(Shangjuxu ST 37 and Tianshu ST 25) to treat the ulcerative colitis(UC). In the view of signal transducers and activators of transcription(STAT-3、STAT-4), we study the in cell signal transduction pathway of Th1/Th2 polarization of UC in rats and patients and the intervention mechanism of acupuncture. We also study the dependability between the effectiveness of meridians and points and equilibrium of Th1/Th2 cells, and analyze the infrared radiation characteristics of some special acupoints. The research discovered that compatibility of meridians and points is the considerable factor for the effect, the compatibility of Shu and Mu, He and Mu are efficacious in treating UC. The rational compatibility could make the synergistic effects; acupuncture and moxibustion could modulate the abnormal state of UC by regulating the in cell signal transduction pathway of Th1/Th2 polarization and activating transcription factors STAT-3 and STAT-4. Infrared spectroscopic study of the special acupoints shows that Shangjuxu(ST 37) etc could reflect the certain pathological information of UC patients in some degree. The results showed that the quality of moxibustion makes difference in the curative effect for UC.
结题摘要
本项目应用"俞募配穴"(大肠俞、天枢) ，"合募配伍" (上巨虚、天枢)治疗溃疡性结肠炎，通过临床与动物实验研究，从信号传导及转录激活因子（STAT-3、STAT-4）信号转导角度，探讨溃疡性结肠炎Th1/Th2细胞极化的细胞内信号转导途径，以及针灸干预的信息传导机制，探讨艾灸经穴效应与 Th1/Th2细胞平衡的相关性，并分析部分相关特定穴的红外辐射特性。研究显示经穴配伍是影响经穴效应的重要因素，俞募配伍、合募配伍是治疗溃疡性结肠炎有效的经穴处方，合理的经穴配伍能够产生协同作用，针灸能够通过调节Th1/Th2细胞极化的细胞内信号转导途径及转录激活因子STAT-3和STAT-4，发挥对溃疡性结肠炎异常免疫功能状态的调节作用。患者特定穴红外光谱研究显示，上巨虚等特定穴在不同程度上都能反映溃疡性结肠炎患者一定的病理的信息。研究并阐释了艾灸治疗溃疡性肠炎效应与灸量有关。