中文摘要
整体研究：①利用低强度聚焦超声脉冲对药物载体微粒（泡）系统进行精细、适形与高效控制释放和②超声实时监控成像的理论与关键技术。重点研究：①同时满足断裂和汽化阈值内低散射系数、阈值上可控释放与高释放率、和断裂与汽化后高散射系数等要求的药物载体微粒（泡）系统结构设计、建模与制备技术；②以全数字化超声成像系统为平台的药物载体微粒（泡）精细控制释放所需要的单（变）焦点与多焦点低强度聚焦超声焦点模式反向合成和控制理论与方法；③利用声光同步超高速显微成像技术对药物载体微粒（泡）在单（变）焦点与多焦点低强度聚焦脉冲超声场中断裂和汽化释放瞬态过程的实验观察与机制分析；④高分辨率、超宽带的控制释放超声监控成像技术；⑤药物载体微粒（泡）制备、体内运载和释放等几个环节可能相关的超声分子生物学效应。研究意义：①将药物控制释放推向精细与适形释放和实时成像监控这一更高层次；②从根本上扩展现有B 型超声成像系统的工作模式。
英文摘要
Generally study: (1) the accurately, compliantly and effectively controlled release of drug-carrier microsphere (microbubble) using low intensity focused ultrasound pulse; (2) the theories and key technologies in ultrasound real-time monitoring imaging. Emphatically study: (1) the structure design, modeling and preparation of drug-carrier microsphere (microbubble) system, which can satisfy all the requirements of a low scattering cross section under fracture and vaporization threshold, controlled release and high release efficiency above the threshold, and high scattering cross section after the fracture and vaporization; (2) inverse synthesize and controlling theories and methods of the single and multiple focuses modal under low intensity focused ultrasound; (3) experimental observation and mechanism analyze of the instantaneous fracture and vaporization controlled release processes in the single and multiple focuses low intensity focused ultrasound field, using acoustic-optical confocal super high-speed microphotographics; (4) high resolution, super broad band controlled release ultrasound monitoring imaging technology; (5) ultrasound molecular biological effects possibly associated with the sections of drug-carrier microsphere preparation, in vivo carry and release. Research significance: (1) push the contro
结题摘要
整体研究：①利用低强度聚焦超声脉冲对药物载体微粒（泡）系统进行精细、适形与高效控制释放和②超声实时监控成像的理论与关键技术。重点研究：①同时满足断裂和汽化阈值内低散射系数、阈值上可控释放与高释放率、和断裂与汽化后高散射系数等要求的药物载体微粒（泡）系统结构设计、建模与制备技术；②以全数字化超声成像系统为平台的药物载体微粒（泡）精细控制释放所需要的单（变）焦点与多焦点低强度聚焦超声焦点模式反向合成和控制理论与方法；③利用声光同步超高速显微成像技术对药物载体微粒（泡）在单（变）焦点与多焦点低强度聚焦脉冲超声场中断裂和汽化释放瞬态过程的实验观察与机制分析；④高分辨率、超宽带的控制释放超声监控成像技术；⑤药物载体微粒（泡）制备、体内运载和释放等几个环节可能相关的超声分子生物学效应。研究意义：①将药物控制释放推向精细与适形释放和实时成像监控这一更高层次；②从根本上扩展现有B 型超声成像系统的工作模式。