枳壳为江西道地药材，具有理气宽中，行滞消胀的功效。生枳壳行气宽中除胀力强，常用于肋胁胀痛，肝气郁结；麸炒后增强了健脾消胀的作用，常用于宿食停滞，呕逆嗳气。枳壳炮制方法记载有20几种，其中麸炒法出现较早，沿用时间最长，文献记载最多，临床应用最广泛，现今仍广为沿用，枳壳有关炮制的目的的论述亦集中于麸炒枳壳上，但其炮制机理目前尚不清楚。本课题以中医理论为基础，结合枳壳的给药途径是以汤剂为主的特点，利用江西新干产枳壳在麸炒前后的高效液相色谱指纹图谱的不同，采用现代分离分析技术，结合现代药理试验，找寻其炮制前后活性物质的变化规律，从而揭示其药效物质基础，阐明其炮制机理，为建立枳壳饮片炮制操作规范及客观评价的质量标准提供科学依据。

Fructus Aurantii (Zhiqiao) is a famous-region drug of Jiangxi province. It has the ability to regulate qi and comfort the middle energizer, to break stagnation and relieve distention. The crude Fructus Aurantii has more powerful effect to relieve distention and promote the circulation of qi. The crude is mainly used to treat hypochondria with pain and liver-qi stagnation. The stir-baked with bran increases the effect to invigorate spleen and relieve distention and it is mainly used to treat food retention, vomiting, nausea, hiccup, belching. There are more than 20 methods of processing Fructus Aurantii. In which the method of stir-baking with bran existed much early, was used for a long history. Also this method was mostly recorded in documents and was widely used in clinical. Even it is used nowadays. Studies on purposes of processing Fructus Aurantii are also focused in the method of stir-baking with bran. However, the processing mechanism has not been clear so far. Based on the basic theory of traditional Chinese medicine, in combination with the features that the major drug administration of Fructus Aurantii is decoction, this research project took modern separation and analysis techniques and modern pharmacological experiments to find transformation rule of active substance of Fructus Aurantii before and

枳壳为江西道地药材，具有理气宽中，行滞消胀的功效。生枳壳行气宽中除胀力强，常用于肋胁胀痛，肝气郁结；麸炒后增强了健脾消胀的作用，常用于宿食停滞，呕逆嗳气。枳壳炮制方法记载有20几种，其中麸炒法出现较早，沿用时间最长，文献记载最多，临床应用最广泛，现今仍广为沿用，枳壳有关炮制的目的的论述亦集中于麸炒枳壳上，但其炮制机理目前尚不清楚。本课题以中医理论为基础，结合枳壳的给药途径是以汤剂为主的特点，利用江西新干产枳壳在麸炒前后的高效液相色谱指纹图谱的不同，采用现代分离分析技术，结合现代药理试验，找寻其炮制前后活性物质的变化规律，从而揭示其药效物质基础，阐明其炮制机理，为建立枳壳饮片炮制操作规范及客观评价的质量标准提供科学依据。