国际国内30多年对人脑胶质瘤的临床研究积累了较多的重要的信号转导通路。在尚未探明这些通路之间的联系之际，又发现胶质瘤与内源性microRNA-21等非编码区中的微小RNA（miRNA）有密切关系。所以，如何整合这些 "原材料"重构一个全方位多层次的信号转导加权网络系统，为胶质瘤的治疗提供有价值的参考是本项目的动机。于是,引出了有多少miRNAs 能够调控那些与人脑胶质瘤细胞相关的蛋白，调控的靶点在哪里等问题。为此，需要提出基于概率统计原理开发miRNAs在3'utr 区域的算法；给出miRNAs与靶蛋白相互指认的预测算法；然后再重构带miRNA调控的胶质瘤细胞信号转导加权的信号通路构成的网络（即，有向加权图）。..本项目到现在为止已经基本完成了原来表述中的主要任务。并在该项目资金的支持下，孵化出来了几个新的生长点，研究进入了成果收获初期，今后与此资金资助的成果还会继续呈报。

The history of the studies for human glubomas is more than 30 years,which collected lot of good experinces on the signaling pathways that may involve the gluboma. The newest discovery that microRNAs(i.e. miRNA-21,etc.) may change the funtions of the signal pathways through the microRNAs binding to the 3'UTR of the proteins on the pathways, which make the question how to construct a global nextwork for gluboma becomes more complicated and confusing. The motivation of this project is how to use these raw materials to construct a global network to help the study of gluboma.Threfore,the most important question is scanning which miRNAs may modulate the profiles of these proteins that on the known local signaling pathways of gluboma. for this purpose, the project is aiming at devoloping the algorithm to scan all valubale targets for arbitary miRNA.and then construct the global network of gluboma with the miRNA modulation...At the end of the this project, the main task is finished and the contributions are published. As well as, many new projects are growing supported by this funding, the submitting papers acknowlegded this grant will be reported to NSFC again in the future.

国际国内30多年对人脑胶质瘤的临床研究积累了较多的重要的信号转导通路。在尚未探明这些通路之间的联系之际，又发现胶质瘤与内源性microRNA-21等非编码区中的微小RNA（miRNA）有密切关系。所以，如何整合这些 "原材料"重构一个全方位多层次的信号转导加权网络系统，为胶质瘤的治疗提供有价值的参考是本项目的动机。于是,引出了有多少miRNAs 能够调控那些与人脑胶质瘤细胞相关的蛋白，调控的靶点在哪里等问题。为此，需要提出基于概率统计原理开发miRNAs在3'utr 区域的算法；给出miRNAs与靶蛋白相互指认的预测算法；然后再重构带miRNA调控的胶质瘤细胞信号转导加权的信号通路构成的网络（即，有向加权图）。本项目到现在为止已经基本完成了原来表述中的主要任务。并在该项目资金的支持下，孵化出来了几个新的生长点，研究进入了成果收获初期，今后与此资金资助的成果还会继续呈报。